Overview
| Uniprot ID | H0UVB7 |
|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase D |
|---|
| Gene Name | PPID |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 341 |
QEIAPEDKAIQAELL |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis
Protein Sequence
10
MSHPSPQAKP
20
SNPSNPRVFF
30
DVDVGGERVG
40
RIVLELFADI
50
VPKTAENFRA
60
LCTGEKGIGP
70
TTGKPLHFKG
80
CPFHRIIKKF
90
MIQGGDFSNQ
100
NGTGGESIYG
110
EKFEDENFHY
120
KHDREGLLSM
130
ANAGPNTNGS
140
QFFITTVPTP
150
HLDGKHVVFG
160
QVIKGIGVAR
170
LLENVEVNGE
180
KPAKLCVIAE
190
CGELKEGDDW
200
GIFPKDGSGD
210
CHPDFPEDSD
220
VDFKDVDKIL
230
LITEDLKNLG
240
NTFFKSQNWE
250
MAIKKYRKVL
260
RYVDSSKAIL
270
PEAAAPRLQP
280
VALSCVLNIG
290
ACKLKLSDWQ
300
GAVDSCLEAL
310
EMDPSNTKAL
320
YRKAQGWQGL
330
KEYDQALADL
340
KKAQEIAPED
350
KAIQAELLKV
360
KQKIKAQKDK
370
EKAVYAKMFA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0016018 |
cyclosporin A binding |
| Molecular Function |
GO:0051879 |
Hsp90 protein binding |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Biological Process |
GO:0071492 |
cellular response to UV-A |
| Biological Process |
GO:0034389 |
lipid droplet organization |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0050714 |
positive regulation of protein secretion |
| Biological Process |
GO:0045070 |
positive regulation of viral genome replication |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.