Search Results

Overview

Uniprot ID	H0UVN5
Protein Name	Elongation factor G, mitochondrial
Gene Name	GFM1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
471	NDLDKFSKGIGRFTR

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRVLGAATAV 20 ALGHRPLFRV 30 PAALGWQRKQ 40 ISWKFCRWCS 50 SGIIPNEKIR 60 NIGISAHIDS 70 GKTTLTERVL 80 YYTGRIAQMH 90 EVKGKDGVGA 100 VMDSMELERQ 110 RGITIQSAAT 120 YTMWKDVNIN 130 IIDTPGHVDF 140 TIEVERALRV 150 LDGAVLVLCA 160 VGGVQCQTMT 170 VNRQMKRYNV 180 PFLTFINKLD 190 RVGSNPARAL 200 QQMRSKLNHN 210 AAFMQIPIGL 220 EGNFKGIIDL 230 IEERAIFFDG 240 DFGQIIRYSE 250 IPGELRAAAA 260 DHRQELIECV 270 ANSDEQLGEM 280 FLEEKIPSIS 290 DLKLAIRRAT 300 LSRAFTPVFL 310 GSALKNKGVQ 320 PLLDAVLEYL 330 PNPSEVQNYA 340 LLNQEDDSKE 350 KTKILMNSKR 360 DNSHPFVGLA 370 FKLEAGRFGQ 380 LTYVRNYQGE 390 LKKGDSIYNT 400 RTGKKVRVQR 410 LVRMHADMME 420 DVEEVYAGDI 430 CALFGIDCAS 440 GDTFTNKDNS 450 GLSMESIHVP 460 DPVISVAMSP 470 SNKNDLDKFS 480 KGIGRFTRED 490 PTFKVHFDTE 500 SKETIVSGMG 510 ELHLEIYAQR 520 MEREYGCPCI 530 TGKPKVAFRE 540 TITAPVPFEF 550 THKKQSGGAG 560 QFGKVIGVLE 570 PLDPENYTKL 580 EFTDDTFGTN 590 VPKQFIPAVE 600 KGFLDACEKG 610 PLSGHKLSGL 620 RFVLQDGAHH 630 MVDSNEISFI 640 RAGEGAVKQA 650 LSSATLCILE 660 PIMAVEIIAP 670 NEFQGSVIAG 680 INRRHGVITG 690 QDGIEDYFTL 700 YADVPLNNMF 710 GYSTELRSCT 720 EGKGEYTMEY 730 CRYQPCLPST 740 QEDLINKYLE 750 ATGQLPIKKG KAKN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0070125	mitochondrial translational elongation

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.