Search Results
Overview
| Uniprot ID | H0UVQ5 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
| Gene Name | PRKAR2A |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 309 | RSKTKTNKDAGNQEV |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSHFQIPPGL
20
TELLQGYTVE
30
VLRRRPPDLV
40
EFAVDYFTRL
50
REARVPVAAA
60
QSGEPEPHAG
70
PDPDTSDASD
80
TDDDEEVEAP
90
VPSRFNRRVS
100
VCAEAYNPDE
110
EEEDTDPRVI
120
HPKTDEQRCR
130
LQEACKDILL
140
FKNLDQEQLS
150
EVLDAMFERT
160
VKVDEHVIDQ
170
GDDGDNFYVI
180
ERGTYDILVT
190
KDNQMRSVGQ
200
YDNRGSFGEL
210
ALMYNTPRAA
220
TIVATSEGAL
230
WGLDRVTFRR
240
IIVKNNAKKR
250
KTFESFIESV
260
PLLKSLEVSE
270
RMKIVDVIGE
280
KNYKDGDRII
290
TQGEKADCFY
300
IVESGEVRIL
310
IRSKTKTNKD
320
AGNQEVEIAR
330
CHKGQYFGEL
340
ALVTNKPRAA
350
SAYAVGNVTC
360
LVMDVQAFER
370
LLGPCMDIMK
380
RNISHYEEQL
390
VKMFGSSLDL
TDPGQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.