Overview
| Uniprot ID | H0UWV1 |
|---|
| Protein Name | WW domain-containing adapter protein with coiled-coil |
|---|
| Gene Name | WAC |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 169 |
VAVNSFPKDRDYRRE |
Function
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway
Protein Sequence
10
CHDRRGDSQP
20
YQALKYSSKS
30
HPSSGDHRHE
40
KMRDAADPSP
50
PNKMLRRSDS
60
PENKYSDSTG
70
HNKAKNVHTH
80
RVREREGGTS
90
YSPQENSHNH
100
SALHSSNSHS
110
SNPSNNPSKT
120
SDAPYDSADD
130
WSEHISSSGK
140
KYYYNCRTEV
150
SQWEKPKEWL
160
EREQRQKEAN
170
KVAVNSFPKD
180
RDYRREVMQA
190
TATSGFAGGK
200
STGDKSVSHS
210
CTTPSTSSAS
220
GLNPTSAPPT
230
SASAVPVSPV
240
PQSPIPPLLQ
250
DPNLLRQLLP
260
ALQATLQLNN
270
SNMDISKINE
280
VLTAAVTQAS
290
LQSIIHKFLT
300
AGPSAFNITS
310
LISQAAQLST
320
QAQPSNQSPM
330
SLTSDASSPR
340
SYVSPRISTP
350
QTNTVPIKPL
360
ISTPPVSSQP
370
KVGTPAVKQG
380
PAAQSATPQQ
390
PVTADKQQGH
400
EPVSPRSLQR
410
SSSQRSPSPG
420
PNHTSSSNAS
430
NAAVVPQNSS
440
ARPACSLTPT
450
LAAHFNESLI
460
KHVQGWPADH
470
AEKQASRLRE
480
EAHNMGSVHM
490
SEICTELKNL
500
RSLVRVCEIQ
510
ATLREQRILF
520
LRQQIKELEK
LKNQNSFMV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0000993 |
RNA polymerase II complex binding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:1904263 |
positive regulation of TORC1 signaling |
| Biological Process |
GO:0010506 |
regulation of autophagy |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.