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Overview

Uniprot IDH0UWX2
Protein NameSerrate RNA effector molecule homolog
Gene NameSRRT
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
285 GKPGEPSKKEEGRAG
719 PLSGKKFKGPEFVRK

Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription

Protein Sequence

10 MGDSDDEYDR 20 RRRDKFRRER 30 SDYDRSRERD 40 ERRRGDDWND 50 REWDRGRERR 60 SRGEYRDYDR 70 NRRERFSPPR 80 HELSPPQKRM 90 RRDWDEHSSD 100 PYHSGYEMPY 110 AGGGGGPTYG 120 PPQPWGHPDV 130 HIMQHHVLPI 140 QARLGSIAEI 150 DLGVPPPVMK 160 TFKEFLLSLD 170 DSVDETEAVK 180 RYNDYKLDFR 190 RQQMQDFFLA 200 HKDEEWFRSK 210 YHPDEVGKRR 220 QEARGALQNR 230 LRVFLSLMES 240 GWFDNLLLDI 250 DRADAIVKML 260 DAAVIKMEGG 270 TENDLRILEQ 280 EEEDEQAGKP 290 GEPSKKEEGR 300 AGAGLGDGER 310 KAGDKDDKKE 320 DGKQVRLVGS 330 RGAGARGRCG 340 GGGGATQVCW 350 RELCSKKRNR 360 KHSGDDSFDE 370 GSVSESESES 380 ESGQAEEDKE 390 ETEEALKEKE 400 KPKEEEREKP 410 KDATGLECKP 420 RPLHKTCSLF 430 MRNIAPNISR 440 AEIISLCKRY 450 PGFMRVALSE 460 PQPERRFFRR 470 GWVTFDRSVN 480 IKEICWNLQN 490 IRLRECELSP 500 GVNRDLTRRV 510 RNINGITQHK 520 QIVRNDIKLA 530 AKLVHTLDDR 540 TQLWASEPGT 550 PPLPTSLPSQ 560 NPILKNITDY 570 LIEEVSAEEE 580 ELLGSSGGAP 590 PEEPPKEGNP 600 AEINVERDEK 610 LIKVLDKLLL 620 YLRIVHSLDY 630 YNTCEYPNED 640 EMPNRCGIIH 650 VRGPMPPNRI 660 SHGEVLEWQK 670 TFEEKLTPLL 680 SVRESLSEEE 690 AQKMGRKDPE 700 QEVEKFVTSN 710 TQELGKDKWL 720 CPLSGKKFKG 730 PEFVRKHIFN 740 KHAEKIEEVK 750 KEVAFFNNFL 760 TDAKRPALPE 770 IKPAQPPGPA 780 QIIHVPVCLT 790 PGLPYPHQTP 800 QGLMPYGQPR 810 PPILGYGAGA 820 VRPAVPTGGP 830 PYPHAPYGAG 840 RGNYDAFRGQ 850 GGYPGKPRSR 860 MVRGDPRAIV 870 EYRDLDAPDD VDFF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Biological Process GO:0031053 primary miRNA processing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.