Overview
| Uniprot ID | H0UWY1 |
|---|
| Protein Name | Vacuolar proton pump subunit B |
|---|
| Gene Name | ATP6V1B2 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 109 |
TSGIDAKKTSCEFTG |
Function
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load
Protein Sequence
10
MALRAMRGMV
20
NGAAPELPVP
30
TSGPVAGARE
40
QALAVSRNYL
50
SQPRLTYKTV
60
SGVNGPLVIL
70
DHVKFPRYSE
80
IVHLTLPDGT
90
KRSGQVLEVS
100
GSKAVVQVFE
110
GTSGIDAKKT
120
SCEFTGDILR
130
TPVSEDMLGR
140
VFNGSGKPID
150
RGPAVLAEDF
160
LDIMGQPINP
170
QCRIYPEEMI
180
QTGISAIDGM
190
NSIARGQKIP
200
IFSAAGLPHN
210
EIAAQICRQA
220
GLVKKCKDVV
230
DYSEENFAIV
240
FAAMGVNMET
250
ARFFKSDFEE
260
NGSMDNVCLF
270
LNLANDPTIE
280
RIITPRLALT
290
TAEFLAYQCE
300
KHVLVILTDM
310
SSYAEALREV
320
SAAREEVPGR
330
RGFPGYMYTD
340
LATIYERAGR
350
VEGRNGSITQ
360
IPILTMPNDD
370
ITHPIPDLTG
380
YITEGQIYVD
390
RQLHNRQIYP
400
PINVLPSLSR
410
LMKSAIGEGM
420
TRKDHADVSN
430
QLYACYAIGK
440
DVQAMKAVVG
450
EEALTSDDLL
460
YLEFLQKFER
470
NFISQGPYEN
480
RSVYETLDIG
490
WQLLRIFPKE
500
MLKRIPQSTL
510
SEFYPRDSTK
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Biological Process |
GO:0097401 |
synaptic vesicle lumen acidification |
| Biological Process |
GO:0007035 |
vacuolar acidification |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0005902 |
microvillus |
| Cellular Component |
GO:0001726 |
ruffle |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Cellular Component |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0046034 |
ATP metabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.