Search Results

Overview

Uniprot ID	H0UWZ9
Protein Name	Protein unc-45 homolog A
Gene Name	UNC45A
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
279	VKKGFRGKEGAIIVE

Function

May act as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin. Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen

Protein Sequence

10 MTVSGPGTPE 20 PRPTIPGASS 30 AEQLRKEGNE 40 LFKCGDYEGA 50 LTAYTQALDL 60 GATPQDRAVL 70 HRNRAACHLK 80 LEEYEKAETE 90 ASKAIDKDGG 100 DVKALYRRSQ 110 ALEKLGRLDQ 120 AVLDLQRCVS 130 LEPKNKVFQE 140 ALRSIGGQIQ 150 EKVRYMSSTD 160 AKVEQMFQIL 170 LDPDEKGTEK 180 KQKASQNLVV 190 LAREDAGAEK 200 IFRNNGVQLL 210 QRLLDTGETD 220 LMLAALRTLV 230 GICSEHQSRT 240 VATLSVLGTR 250 RVVSILGVEN 260 QAVSLAACHL 270 LQVMFDALRE 280 GVKKGFRGKE 290 GAIIVEPGRE 300 LKVLITNLLE 310 LLTEVGVSGQ 320 GRDNALTLLI 330 KMVPRKSPKD 340 PDNSLTLWII 350 DQGLKKILQV 360 GGSLQDPAGE 370 LAVTANSRMS 380 ASILLSKLFD 390 DLKCDAEREN 400 FHRLCESYIK 410 SWFEGQGLAG 420 KLRAIQTVSC 430 LLQGPCDAGN 440 RALELSGVME 450 SVIALCASEQ 460 EEEQLVAVEA 470 LIHAAGKAKR 480 ASFITASGVS 490 LLKDLYKRSE 500 KDSIRIRALV 510 GLCKLGSAGG 520 TDFSMKQFAE 530 GSTLKLAKQC 540 RKWLCNEQID 550 AGTRRWAVEG 560 LAYLTFDADV 570 KEEFVEDGAA 580 LKALFQLSRS 590 EERSVLFAVA 600 SALVNCTNSY 610 DYEEPDPKMV 620 ELAKYAKQHV 630 PEQHPKDKPS 640 FVQVRVKKLL 650 AAGVVSAMTC 660 MVKTESPVLT 670 NSCRELLSRV 680 FLALVEEVED 690 RGVVVAQGGG 700 KALIPLALEG 710 TEVGQTKAAQ 720 ALAKLTITSN 730 PEMTFPGERI 740 YEVVRPLVSL 750 LHLDRSGLQN 760 FEALMALTNL 770 AGISERLQQK 780 ILKEKAVPMI 790 EGYMFEEHEM 800 LRRAATECMC 810 NLAMNKEVQD 820 LFEAEGNDRL 830 KLLVLYSGED 840 DELLRRAAAG 850 GLAMLTSARP 860 SLCSRIPQVT 870 THWLEILQAL 880 LLSPNQELQH 890 RGAVVVLNMV 900 EASREIASTL 910 MESEVLEILS 920 VLAKGKEGPV 930 ARAAAACLVK 940 AVEYGLIQPN QGAE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0051879	Hsp90 protein binding
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007517	muscle organ development

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.