Overview
| Uniprot ID | H0UX04 |
|---|
| Protein Name | Protein VAC14 homolog |
|---|
| Gene Name | VAC14 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 355 |
RQSEPNPKDSVAKQA |
Function
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes
Protein Sequence
10
MNPEKDFAPL
20
TPNIVRALND
30
KLYEKRKVAA
40
LEIEKLVREF
50
VAQNNTVQIK
60
HVIQTLSQEF
70
ALSQHPHSRK
80
GGLIGLAACS
90
IALGKDSGLY
100
LKELIEPVLT
110
CFNDADSRLR
120
YYACEALYNI
130
VKVARGAVLP
140
HFNVLFDGLS
150
KLAADPDPNV
160
KSGSELLDRL
170
LKDIVTESNK
180
FDLVGFIPLL
190
RERIYSNNQY
200
ARQFIISWIL
210
VLESVPDINL
220
LDYLPEILDG
230
LFQILGDNGK
240
EIRKMCEVVL
250
GEFLKEIKKN
260
PSSVKFAEMA
270
NILVIHCQTT
280
DDLIQLTAMC
290
WMREFIQLAG
300
RVMLPYSSGI
310
LTAVLPCLAY
320
DDRKKSIKEV
330
ANVCNQSLMK
340
LVTPEDDEPD
350
ELKPAVQRQS
360
EPNPKDSVAK
370
QAGAASGGPD
380
GSCDSSFSSG
390
ISVFTPVSTD
400
RAPVTLNLDG
410
IVQVLNCHLS
420
DMTIGMMTRI
430
AVLKWLYHLY
440
IKTPRKMFRH
450
TDSLFPILLQ
460
TLSDESDEVV
470
LKDLEVLAEI
480
ASSPAGQTDE
490
PGPADGPDLR
500
VSHSELQVPT
510
PSRGSLLNTA
520
STKGLECSPS
530
TPTMNSYFYK
540
FMINLLQRFS
550
SEQLCLLLNA
560
ENIFHSMADI
570
LLREEDLKFA
580
STMVHTLNTI
590
LLTSTELFQL
600
RNQLKDLKTL
610
ESQNLFCCLY
620
RSWCHNPVTT
630
VSLCFLTQNY
640
RHAYDLIQKF
650
GDLEVTVDFL
660
TEVDKLVQLI
670
ECPIFTYLRL
680
QLLDVKNNPY
690
LIKALYGLLM
700
LLPQSSAFQL
710
LSHRLQCVPN
720
PELLQTEDSL
730
KAAPKSQKGD
740
SANIDYTELL
750
QHFEKVQNQH
760
LEVRHQRSGR
770
GDHLDRRVVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070772 |
PAS complex |
| Cellular Component |
GO:0098830 |
presynaptic endosome |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Biological Process |
GO:1903100 |
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process |
| Biological Process |
GO:0006661 |
phosphatidylinositol biosynthetic process |
| Biological Process |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.