Search Results
Overview
| Uniprot ID | H0UX23 |
|---|---|
| Protein Name | Creatine kinase U-type, mitochondrial |
| Gene Name | LOC100725326 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | VDALSGLKGDLAGRY |
| 275 | TRVISMEKGGNMKRV |
| 337 | IKLPLLSKDNRFPKI |
| 402 | DCERRLEKGQDIRIP |
| 416 | PAPLIHNKH****** |
| 58 | AEYPDLRKHNNCMAS |
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
Protein Sequence
10
MAGVFSRLPS
20
ARPGLRLLAM
30
AGAGSLVAGF
40
LLRPDSVQAS
50
RERRRLYPPS
60
AEYPDLRKHN
70
NCMASHLTPA
80
VYARLCDKTT
90
PTGWTLDQCI
100
QTGVDNPGHP
110
FIKTVGMVAG
120
DEETYEVFAE
130
LFDPVIQERH
140
NGYDPRTMKH
150
TTDLDASKIR
160
SGYFDERYVL
170
SSRVRTGRSI
180
RGLSLPPACS
190
RAERREVERV
200
VVDALSGLKG
210
DLAGRYYRLS
220
EMTEAEQQQL
230
IDDHFLFDKP
240
VSPLLTAAGM
250
ARDWPDARGI
260
WHNNEKSFLI
270
WVNEEDHTRV
280
ISMEKGGNMK
290
RVFERFCRGL
300
KEVERLIQER
310
GWEFMWNERL
320
GYILTCPSNL
330
GTGLRAGVHI
340
KLPLLSKDNR
350
FPKILENLRL
360
QKRGTGGVDT
370
AATGSVFDIS
380
NLDRLGKSEV
390
ELVQLVIDGV
400
NYLIDCERRL
410
EKGQDIRIPA
PLIHNKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004111 | creatine kinase activity |
| Biological Process | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| Biological Process | GO:0046314 | phosphocreatine biosynthetic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.