Search Results
Overview
| Uniprot ID | H0UY79 |
|---|---|
| Protein Name | Hsc70-interacting protein |
| Gene Name | St13 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 153 | RLAILYAKRASVFIK |
| 349 | SKYQSNPKVMNLISK |
| 50 | PPATHKAKSEENIKE |
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins
Protein Sequence
10
MDPRKVNELR
20
AFVKMCKQDP
30
SVLHTEEMRF
40
LREWVESMGG
50
KVPPATHKAK
60
SEENIKEEKT
70
DSKKTEENIK
80
TDEPSSEESD
90
LEIDNEGVIE
100
PDTDSPQEMG
110
DENVEITEEM
120
MDQANEKKGA
130
AIDALNDGEL
140
QKAIDLFTDA
150
IKLNPRLAIL
160
YAKRASVFIK
170
LQKPNAAIRD
180
CDRAIEINPD
190
SAQPYKWRGK
200
AHRLLGHWEE
210
AAHDLALACK
220
LDYDEDASAM
230
LKEVQPRAQK
240
IAEHRRKYER
250
KREEREIKER
260
IERVKKAREE
270
HEKAQREEPR
280
RQSGAQYGSF
290
PGGFPGGMPG
300
NFPGGMPGMG
310
AGMAGMPGLN
320
EILSDPEVLA
330
AMQDPEVMVA
340
FQDVAQNPAN
350
MSKYQSNPKV
360
MNLISKLSAK
FGGQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.