Search Results
Overview
| Uniprot ID | H0UYI6 |
|---|---|
| Protein Name | D-aminoacyl-tRNA deacylase |
| Gene Name | DTD1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 162 | SDPKQLSKLEKQQQR |
| 190 | KERTAPRKEDCSASS |
Function
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
Protein Sequence
10
MKAVVQRVTR
20
ASVTVGGEQV
30
SAIGRGLCVL
40
LGISLEDSQK
50
EVEHMVRKIL
60
NLRVFEDDSG
70
KHWSKSVMDK
80
QFEVLCVSQF
90
TLQCVLKGSK
100
PDFHLAMPAE
110
QAEGFYNSFL
120
EQLRKTYRPE
130
LIKDGKFGAY
140
MQVHIQNDGP
150
VTIELESPAP
160
SAAISDPKQL
170
SKLEKQQQRK
180
EKIRAKGPSE
190
SSKERTAPRK
200
EDCSASSGAE
GDVSSEREP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0051500 | D-tyrosyl-tRNA(Tyr) deacylase activity |
| Molecular Function | GO:0000049 | tRNA binding |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.