Search Results
Overview
| Uniprot ID | H0UYU8 |
|---|---|
| Protein Name | Mitotic spindle assembly checkpoint protein MAD1 |
| Gene Name | MAD1L1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 61 | RAEQIRSKSYLIQVE |
| 87 | RARVELEKAASTSAR |
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling
Protein Sequence
10
MEDLGENTTV
20
LSTLRSLNNF
30
ISQRVEGESG
40
LDTSTSASGS
50
LQMQYHQSIQ
60
LEERAEQIRS
70
KSYLIQVERE
80
KMQMELSHKR
90
ARVELEKAAS
100
TSARNYEREV
110
DRNQELLARL
120
RQYQDREAEA
130
EEKMREQLER
140
HRVCRQNLDS
150
ASQQLREQEN
160
SLAVASETIG
170
TLKGQVSELQ
180
WSLMDQEVQV
190
KRLESEKQEL
200
QEQLDLQHRK
210
WQEANQKIQE
220
LQASQEAKAD
230
QEQKIKDLEQ
240
KLCLQEQDAA
250
VVRNMKSELL
260
RLPRVERELK
270
RLREENAHLR
280
EMRDTNGLLM
290
EELEGLQRRL
300
GRQEKMQEAL
310
VGLELEKERL
320
LTKLQSWEIL
330
DQTTGLNLRT
340
PEDLSNFIVE
350
LQQRELALKE
360
KNSAITISAR
370
GLEKAQQQLQ
380
EEVRQVSGQL
390
LEERKKRENH
400
EALARRLQKR
410
VLLLTKERDG
420
MRAILGSYDS
430
ELTQAEYSPQ
440
LTRRMREAED
450
MVQKMHAHSS
460
EMEAQLSQAM
470
EELGGQKQRA
480
DMLEMELKML
490
KSQPSSAEPS
500
FPFCREEMDT
510
LRSKVEELEA
520
ERSRLEQEKN
530
VLEMQLERRT
540
LQGDYDQSKT
550
KVLHMSLNPT
560
SLAKQRLREE
570
RDRLQEECER
580
LRGLVHALER
590
GGPVPADLEA
600
TTGLASSKEV
610
AELRKQVESA
620
ELKNQRLKEV
630
FQTKIQEFRK
640
VCYTLTGYQI
650
DITTENQYRL
660
TSQYAEHKTD
670
CLIFKATGPS
680
GSKMQLLETE
690
FSRSVPELIE
700
LHLLRQDSIP
710
AFLSALTLEL
FSHQTAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:1990706 | MAD1 complex |
| Cellular Component | GO:1990728 | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
| Cellular Component | GO:0097431 | mitotic spindle pole |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0044615 | nuclear pore nuclear basket |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0043515 | kinetochore binding |
| Biological Process | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| Biological Process | GO:0090235 | regulation of metaphase plate congression |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.