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Overview

Uniprot ID	H0UZA4
Protein Name	Far upstream element-binding protein 1
Gene Name	FUBP1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
394	KTGLIIGKGGETIKS

Function

Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription

Protein Sequence

10 MADYSTVPPP 20 SSGSAGGGGG 30 GGGGGGVNDA 40 FKDALQRARQ 50 IAAKIGGDAG 60 TSLNSNDYGY 70 GGQKRPLEDG 80 DQPDAKKVAP 90 QNDSFGSQLP 100 PMHQQQSRSV 110 MTEEYKVPDG 120 MVGFIIGRGG 130 EQISRIQQES 140 GCKIQIAPDS 150 GGLPERSCML 160 TGTPESVQSA 170 KRLLDQIVEK 180 GRPAPGFHHG 190 DGPGNAVQEI 200 MIPASKAGLV 210 IGKGGETIKQ 220 LQERAGVKMV 230 MIQDGPQNTG 240 ADKPLRITGD 250 PYKVQQAKEM 260 VLELIRDQGG 270 FREVRNEYGS 280 RIGGNEGIDV 290 PIPRFAVGIV 300 IGRNGEMIKK 310 IQNDAGVRIQ 320 FKPDDGTTPD 330 RIAQITGPPD 340 RCQHAAEIIT 350 DLLRSVQAGN 360 PGGPGPGGRG 370 RGRGQGNWNM 380 GPPGGLQEFN 390 FIVPTGKTGL 400 IIGKGGETIK 410 SISQQSGARI 420 ELQRNPPPNA 430 DPNMKLFTIR 440 GTPQQIDYAR 450 QLIEEKIGGP 460 VNPLGPPVPH 470 GPHGVPGPHG 480 PPGPPGPGAP 490 MGPYNPAPYN 500 PGPPGPAPHG 510 PPAPYAPQGW 520 GNAYPHWQQQ 530 APPDPAKAGT 540 DPNSAAWAAY 550 YAHYYQQQAQ 560 PPPAAPTGAP 570 TATQTNGQGN 580 YGDQQNPAPA 590 GQVDYTKAWE 600 EYYKKMGQAV 610 PAPAGAPPGG 620 QPDYSAAWAE 630 YYRQQAAYYA 640 QTSPQGMPQH 650 PPAPQGFANH ARSHHHLY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0006355	regulation of DNA-templated transcription

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.