Search Results
Overview
| Uniprot ID | H0UZZ9 |
|---|---|
| Protein Name | heme oxygenase (biliverdin-producing) |
| Gene Name | HMOX2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | KNPVAPEKENHIRMP |
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron
Protein Sequence
10
MSAEVETSEG
20
VDELERKNPV
30
APEKENHIRM
40
PDLSELLKEG
50
TKEAHDRAEN
60
TQFVKDFLKG
70
NIKKELFKLA
80
TTALYFTYSA
90
LEEEMDRNKD
100
HSAFAPLYFP
110
MELHRKEALT
120
KDMAYFFGEN
130
WEEQVMCSQA
140
TQKYVERIHY
150
VGQNEPELLV
160
AHAYTRYMGD
170
LSGGQVLKKV
180
AQRALKLPST
190
GEGTQFYQFE
200
NVDNAQQFKQ
210
FYRARMNALD
220
LSLKTKERIV
230
EEANKAFEYN
240
MQIFDELDQA
250
GSMLARDTLE
260
DGFPVHDGKG
270
DIRKCPFYTA
280
QQDKGALEGN
290
SCPFRTAISV
300
LRKPSLQLIL
310
ATSVALAAGL
LAWYYI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0004392 | heme oxygenase (decyclizing) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0042167 | heme catabolic process |
| Biological Process | GO:0006788 | heme oxidation |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.