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Overview

Uniprot IDH0V0M5
Protein NameLupus La protein homolog
Gene NameSSB
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
319 DQQESLNKWKSKGRR
345 QPGSAKGKVQFQGKK
351 GKVQFQGKKTKFDSD

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation

Protein Sequence

10 MAENGDNEKM 20 AALEAKICHQ 30 IEYYFGDFNL 40 PRDKFLKEQI 50 KLDEGWVPLE 60 IMIKFNRLNR 70 LTTDFNVIVE 80 ALSKSKAELM 90 EISEDKTKIR 100 RSPNKPLPEV 110 TDEYKNDVKN 120 RSVYIKGFPT 130 DATLDDIKEW 140 LEDKGQVLNI 150 QMRRTLHKAF 160 KGSIFAVFDS 170 IESAKKFVET 180 PGQKYKDTDL 190 LILFKEDYFA 200 KKNEERKQNK 210 VEAKLRAKQH 220 KVSFKSLEEK 230 IGCLLKFSGD 240 LDDQTCREDL 250 HALFSNHGEI 260 KWIDFVRGAK 270 EGIILFKEKA 280 KEALEKAKDA 290 NNGSLQLRNK 300 EVTWEVLEGE 310 VEKEALKKII 320 EDQQESLNKW 330 KSKGRRFKGK 340 GKGNKAAQPG 350 SAKGKVQFQG 360 KKTKFDSDEE 370 RGPVKRAREE 380 TDKEEPASKQ 390 QKTENGAGDQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003729 mRNA binding
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0008033 tRNA processing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.