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Overview

Uniprot ID	H0V1T6
Protein Name	General transcription factor 3C polypeptide 2
Gene Name	GTF3C2
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
155	KGDLLLLKLSKGLDQ

Function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1

Protein Sequence

10 MDTCGVGCVA 20 LGEAGPVGNM 30 TVVDSPGQEV 40 LKQLGVKAPS 50 ETASMEASIE 60 MSLPTPLPGF 70 EDCPDMRSLP 80 PEQESLSRLE 90 QQDLSSEMSK 100 VSNPRASKPG 110 RKRGGRTRKG 120 PKRPQQRKAP 130 TAPLVPGLLD 140 QSNPLSTPMP 150 KKRSQKSKGD 160 LLLLKLSKGL 170 DQPESPPSKR 180 PPEDFETSSG 190 ERPRRRAAQV 200 ALVYLQELAE 210 ELSSTLPAPV 220 TCPKSPKASS 230 PTTVKKTQPQ 240 AACHGGEEDA 250 AAQDEDFVLQ 260 VEAEDGAESE 270 APSEALSDPE 280 PIVPRSTPRG 290 STSGKQKPHC 300 RGMAPNGLPN 310 YIMAPVWKCL 320 HLTKDLREQM 330 HSLWEFAEWI 340 PLAWKWHLLS 350 ELEAAPYLPQ 360 EEKSPLFSVQ 370 REGLSEDGTL 380 YRINRFSSVT 390 AHPERWDVSF 400 FTGGPLWALD 410 WCPVPEGSAA 420 SQYVALFSSP 430 DMNETHPLSQ 440 LHSGPGLLQL 450 WGLGTLQPES 460 CSGNRAHFVY 470 GIACDHGCIW 480 DLKFCPSGAW 490 ELPGTLRKAP 500 LLPRLGLLAL 510 ACSDGKVLLF 520 SLPHPEALLA 530 QQPPDAMKPA 540 IYKVQCVATL 550 QVGSMQASDP 560 SECGQCLSLA 570 WMPTRPHHHL 580 AAGYYNGMVV 590 FWNLPTNSPL 600 LRIRLSDGSL 610 KLYPFQCFLA 620 HDQAVRTLQW 630 CKANSHFLVS 640 AGSDRKIKFW 650 DLRRPYEPIN 660 SIKRFLSTEL 670 AWLLPYNGVT 680 VAQDNCYASY 690 GLCGIHYIDA 700 GYLGFKAYFT 710 APRKGTVWSL 720 SGSDWLGTIA 730 AGDISGELIA 740 AILPDMASNP 750 INVKRPAERR 760 FPIYKADLVP 770 YQDSPEGQDL 780 SSASSGIPDP 790 PKARTYAETV 800 NHHYLLFQDT 810 DLGSFHNLLH 820 REPMLRMQEG 830 EGHSQLCLDR 840 LQLEAIHKVR 850 FSPNLDSYGW 860 LVSGGQSGLV 870 RIHFIRGLTS 880 PLGHRVQLES 890 QAHFSAMFQP 900 SSPTKGPGFP 910 PASHRLLSSP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0000127	transcription factor TFIIIC complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0000995	RNA polymerase III general transcription initiation factor activity
Biological Process	GO:0006384	transcription initiation at RNA polymerase III promoter

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.