Overview
| Uniprot ID | H0V265 |
| Protein Name | Nuclear pore complex protein Nup153 |
| Gene Name | NUP153 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 957 |
TEGFKFSKATNSNFK |
Function
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)
Protein Sequence
10
MASGAGAGAG
20
GGGGGGGVGG
30
GGKIRTRRCH
40
QGPIKPYQQG
50
RPQRQGILSR
60
VTESVKNIVP
70
GWLQRYFSKN
80
EDACRCLTDT
90
NEVPHWPENR
100
EDDHVMYDSE
110
QSAAINDGRI
120
TPELPVSNAE
130
EPSTTSTTSN
140
YPDVLTRPSL
150
HRSHLNFSVL
160
ESPALHCQPS
170
TSSAFPIGSS
180
GFSLVKEIKD
190
STSQHDDDNI
200
STTSGFSSRA
210
SDKDIAISKN
220
TSLPHLWSPE
230
PDRSQSVSQH
240
TASSSKKPAF
250
NLSAFGTLSP
260
SLGNSSNTKT
270
SQLGDSPFYP
280
GKTTYGGAAA
290
AVRQLKLQST
300
PYQAPVRKQM
310
KAKQLNTQSY
320
GVTSSTARRI
330
LQSLEKMSSP
340
LADVKRIPSV
350
VSSMNSPLDR
360
SGIDNTAFWS
370
KRQKVDSQHP
380
PVQRLMTPKP
390
ISIATNRTVY
400
FKPSLTPSGE
410
LRKTNQRIDK
420
KDNTGYEKNM
430
TLRQNREQES
440
GFSYPNFSIP
450
AANGLSSGVG
460
GGGGKMRRER
470
TRVVASKPLE
480
EEEMDIPVLP
490
KISLPISSSS
500
LPTFNFSSPE
510
ITTSCPSSFS
520
PQSLTHKVQM
530
TSPSNTGSPV
540
FRFSSPIVIS
550
TEAVVLSPSS
560
IRFTFSMPVA
570
KTEISGSSST
580
SEPITSSSAQ
590
DNIAVNSTNC
600
KKQSEDYESI
610
LKPAKVLKEG
620
SVLDVLKSPG
630
FTSPKVDLVA
640
SQPTTTSSEV
650
YTRPAISTFS
660
SGGVGFGESV
670
KAGSYWHCDT
680
CLLQNKVTDN
690
KCIACQAVKS
700
TPGESAKQTG
710
TGTPSKSVKA
720
ALSASGTGFG
730
DKFKPAIGSW
740
DCDTCLVRNK
750
PEAMKCVACE
760
TPKPGTGVKR
770
PLTLTVVSES
780
AVTTTASSSN
790
CTVTSGTLGF
800
GDKFKRPVGS
810
WDCTVCCVSN
820
NAEDSKCVAC
830
MSEKPGISVP
840
ASSSSTVPIS
850
VSSGSCLGLD
860
KFKKPEGSWD
870
CEVCLVQNKA
880
DSVKCVACES
890
GKPGTKSEFK
900
GFGTSSSSSN
910
SPASSFKFGI
920
PSSSSGPSQT
930
LTNTGPFKFG
940
DQGGFKTGIS
950
SDSGSVNTMT
960
EGFKFSKATN
970
SNFKFGVSSD
980
SKTEDVKKDS
990
KNDNNFKFGL
1000
SSGVSNPTSA
1010
PFQFGMSNPG
1020
QQEKKEEPSK
1030
SSSAGFSFGT
1040
GVINPIVAAA
1050
AADTVVTSEN
1060
KTSFSFGTTE
1070
TKSVSVAPFT
1080
CKTIEAKKEE
1090
MPATKGGFTF
1100
GNMETAPLPS
1110
ASMFDLERTE
1120
EKQKEPVTST
1130
SLVFGKKADS
1140
EEPKCQQVFS
1150
FGNSEQTKDE
1160
SSSKAIFSFS
1170
IAKPPEKESE
1180
QPAKATFTFG
1190
AQTSTTSDQS
1200
TAKPIFNFLN
1210
NSSSSSSTPA
1220
SSAGGGIFGS
1230
STSSSNPPMA
1240
AFVFGQANNP
1250
VSSSAFGNSA
1260
ESSTSQSLLF
1270
SQDSKPATTS
1280
STGTAVNPFV
1290
FGPGSSSNNT
1300
TATSGFSFGA
1310
TTTSSAAGSS
1320
FVFGPGPSAP
1330
SASTTFGANQ
1340
TPTFGQSQGA
1350
SQPNPPSFAS
1360
ISSSTALFSA
1370
GSQPAPPTFG
1380
TVSSSTQAPV
1390
FGQQPSQSAF
1400
GSGTTPNSSS
1410
VFQFGSSSTT
1420
NFNFTNNNPS
1430
GVFTFGANPS
1440
TPAASAQPSG
1450
SGNFPFSQSA
1460
AAFTVGSNGK
1470
NMFSSPGTSV
1480
PGRKIKTAVR
RKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0042405 |
nuclear inclusion body |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0034399 |
nuclear periphery |
| Cellular Component |
GO:0044615 |
nuclear pore nuclear basket |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:0008139 |
nuclear localization sequence binding |
| Molecular Function |
GO:0043495 |
protein-membrane adaptor activity |
| Molecular Function |
GO:0017056 |
structural constituent of nuclear pore |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:1990000 |
amyloid fibril formation |
| Biological Process |
GO:0051028 |
mRNA transport |
| Biological Process |
GO:0046832 |
negative regulation of RNA export from nucleus |
| Biological Process |
GO:0051292 |
nuclear pore complex assembly |
| Biological Process |
GO:0006606 |
protein import into nucleus |
| Biological Process |
GO:0006405 |
RNA export from nucleus |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.