Search Results
Overview
| Uniprot ID | H0V2Y8 |
|---|---|
| Protein Name | Zinc finger protein 512 |
| Gene Name | ZNF512 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | ESGGVLAKGKRKLKQ |
| 119 | DYGEFPQKKHKLYGR |
| 131 | YGRKQRPKTQPAPKP |
| 553 | PGAAQFQKAKPPKTN |
Function
Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation
Protein Sequence
10
MSSTLGAVPA
20
TPGPTSFKQQ
30
RSARIVGAKN
40
SRTQCSPIKD
50
NSFQYTIPHD
60
DSLSGSSASS
70
CEQVNDFPAS
80
FRKSSYWRKM
90
RRIKQAASPP
100
IEESGGVLAK
110
GKRKLKQEDD
120
EDYGEFPQKK
130
HKLYGRKQRP
140
KTQPAPKPQA
150
RRIPKEPPVY
160
AAGSLEEQWY
170
LEIVEKGSVS
180
CPTCQAVGRK
190
TIEGLKKHME
200
NCKQEKFTCH
210
HCGKQLRSLA
220
GMKYHVMANH
230
NLPILKAGDE
240
IDEPRERERL
250
RKVLKRLGKL
260
RCSRESCSST
270
FTSIMGYVYH
280
VRKCGKAAAE
290
LEKMTLKCHH
300
CGKPYRSKAG
310
LAYHLRSEHA
320
PISFFPESGQ
330
TECLKEMGLE
340
AKSGGRVQRR
350
SAKIAVYHLQ
360
ELASVELAKE
370
WPKRKVLQDL
380
VPDDRKLKYT
390
RPGLPTFSQE
400
VLHKWKTDVK
410
KYHRIQCPNQ
420
GCEAVYSSVS
430
GLKAHLGSCT
440
LGTFVAGKYQ
450
CLLCQKEFVS
460
ESGVKYHINS
470
VHAEDWFVVN
480
PTTTKSFEKL
490
MKIKQKQQEE
500
EKRRQQHRSS
510
RSLRRRQQAG
520
SELPEAQLSL
530
RAGKEQRRSN
540
EELAAWTSCK
550
EAEQEPGAAQ
560
FQKAKPPKTN
HKRGRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0140719 | constitutive heterochromatin formation |
| Biological Process | GO:0006351 | DNA-templated transcription |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.