Search Results
Overview
| Uniprot ID | H0V3I8 |
|---|---|
| Protein Name | Tubulin alpha chain |
| Gene Name | TUBA4A |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 326 | YRGDVVPKDVNAAIA |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MRECISVHVG
20
QAGVQMGNAC
30
WELYCLEHGI
40
QPDGQMPSDK
50
TIGGGDDSFT
60
TFFCETGAGK
70
HVPRAVFVDL
80
EPTVIDEIRN
90
GPYRQLFHPE
100
QLITGKEDAA
110
NNYARGHYTI
120
GKEIIDPVLD
130
RIRKLSDQCT
140
GLQGFLVFHS
150
FGGGTGSGFT
160
SLLMERLSVD
170
YGKKSKLEFS
180
IYPAPQVSTA
190
VVEPYNSILT
200
THTTLEHSDC
210
AFMVDNEAIY
220
DICRRNLDIE
230
RPTYTNLNRL
240
ISQIVSSITA
250
SLRFDGALNV
260
DLTEFQTNLV
270
PYPRIHFPLA
280
TYAPVISAEK
290
AYHEQLSVAE
300
ITNACFEPAN
310
QMVKCDPRHG
320
KYMACCLLYR
330
GDVVPKDVNA
340
AIAAIKTKRS
350
IQFVDWCPTG
360
FKVGINYQPP
370
TVVPGGDLAK
380
VQRAVCMLSN
390
TTAIAEAWAR
400
LDHKFDLMYA
410
KRAFVHWYVG
420
EGMEEGEFSE
430
AREDMAALEK
440
DYEEVGIDSY
EDEDEGEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005874 | microtubule |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.