Search Results
Overview
| Uniprot ID | H0V3J6 |
|---|---|
| Protein Name | Aspartate--tRNA ligase, cytoplasmic |
| Gene Name | DARS1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 74 | HTSRAKGKQCFLVLR |
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA
Protein Sequence
10
MPSASASRRS
20
QEKPREIMDA
30
AEDYAKERYG
40
ISSMIQSQEK
50
PDRVLALVKD
60
LTIQKADEVV
70
WVRARVHTSR
80
AKGKQCFLVL
90
RQQQFNVQAL
100
VAVGDHASKQ
110
MVKFAANINK
120
ESIVDVEGIV
130
RKVNQKIGSC
140
TQQDVELHVQ
150
KIYVISLAEP
160
RLPLQLDDAV
170
RPEVGEEEGR
180
ATVNQDTRLD
190
NRVIDLRTST
200
SQAIFRLQSG
210
ICYLFRETLN
220
NKGFVEIQTP
230
KIISAASEGG
240
ANVFTVSYFK
250
NNAYLAQSPQ
260
LYKQMCICAD
270
FDKVYCIGPV
280
FRAEDSNTHR
290
HLTEFVGLDI
300
EMAFNYHYHE
310
VLEEIADTLV
320
QIFKGLQERY
330
QTEIQTVNKQ
340
FPCEPFKFLE
350
PTLRLEYCEA
360
LAMLREAGVE
370
MGDEEDLSTP
380
NEKLLGRLVK
390
EKYDTDFYIL
400
DKYPLAVRPF
410
YTMPDPRNPK
420
QSNSYDMFMR
430
GEEILSGAQR
440
IHDPQLLTER
450
ALHHGIDLEK
460
IKAYIDSFRF
470
GAPPHAGGGI
480
GLERVTMLFL
490
GLHNVRQTSM
500
FPRDPKRLTP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0004815 | aspartate-tRNA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006422 | aspartyl-tRNA aminoacylation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.