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Overview

Uniprot ID	H0V3X4
Protein Name	S1 RNA-binding domain-containing protein 1
Gene Name	SRBD1
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
110	LDTAQTLKTAKTKRK

Function

DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence

Protein Sequence

10 MSSLPRRAKV 20 QVQTAVSKEE 30 YSYFSELSSA 40 SEEDDKEDTV 50 WEPQKKVPKA 60 RKQPAPKESK 70 PKRVPGGKKN 80 TALTSGGSEC 90 MAVKEELNRS 100 IAIADVDLQE 110 TKLDTAQTLK 120 TAKTKRKNPA 130 QRTKKLKVHE 140 ETITVNNLVD 150 GAEIPSTSTM 160 GEGVCKKEES 170 EDDFTFGQSP 180 LKRMKTETCP 190 QGQPVKFPGS 200 ANTIKEEVEM 210 NWDIVQVLSE 220 RTNIELWVCA 230 NIIRLFNDDN 240 TIPFIVRYRK 250 ELINNLDADS 260 LREVRQTLEE 270 LRMVAKKVHS 280 TIQKIKKEGK 290 MSECLLKALL 300 NCRSFEELEH 310 VSAPYKSGSK 320 GTKAQRAKQL 330 GLEAAAKTLL 340 ENPGQLNLLS 350 YIRSDVKGLS 360 ALQDIETGVQ 370 HILADMIAKD 380 KDTLDFIRKL 390 CQNRYICIQS 400 SLAKVSSKKV 410 NEKDVDKFQL 420 YQNFSCNIRN 430 IQHHQILAIN 440 RGENLKILTV 450 KVNISDGIKN 460 EFCRWCIQNR 470 WRPHGFARPE 480 LMKILHNSLD 490 DSFKRLIYPL 500 LCREFRAKLT 510 SDAEKESVMM 520 FGRNLRQLLL 530 TSPVPGRTLM 540 GVDPGYKHGC 550 KLAIISPTSQ 560 ILHTDVVYLH 570 CGQGFREAEK 580 IKRLLLNFNC 590 STVVIGNGTA 600 CRETEAYFAD 610 LIMKNYFAPL 620 DVVYCIVSEA 630 GTSIYSVSPE 640 ANKEMPGLDP 650 NVRSAVSIAR 660 RVQDPLAELV 670 KIEPKHIGVG 680 MYQHDVSQTL 690 LKATLDSVVE 700 ECVSFVGVDI 710 NICSEVLLRH 720 IAGLNANRAK 730 NIIEWREKNG 740 PFINREQLKK 750 VKGLGPKSFQ 760 QCAGFIRINQ 770 DYIRTFCSQQ 780 TESSSAEVTN 790 EKQGKKKSKT 800 TVDAILKPNP 810 LDQTCIHPES 820 YDIAMRFLLF 830 IGGTLGEIGK 840 PEMQQKINSF 850 LDKEGIEKAA 860 ERLKTTVHTL 870 QVVIDGLSQP 880 ESFDFRTDFD 890 KPDFKRSIVC 900 LEDLQVGTIL 910 TGKVENATLF 920 GIFVDIGVGQ 930 SGLIPIRNVT 940 EAKLSKTKKR 950 RSLGLGPGER 960 VEVRVLNINI 970 PRSRITLDLI RVL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003735	structural constituent of ribosome
Biological Process	GO:0006139	nucleobase-containing compound metabolic process
Biological Process	GO:0006412	translation

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.