Overview
| Uniprot ID | H0V4P0 |
|---|
| Protein Name | Microtubule-associated protein RP/EB family member 3 |
|---|
| Gene Name | MAPRE3 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 151 |
QIFNKSKKLIGTAVP |
| 167 |
RTSPTGPKNIQTSGR |
Function
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules
Protein Sequence
10
MAVNVYSTSV
20
TSENLSRHDM
30
LAWVNDSLHL
40
NYTKIEQLCS
50
GAAYCQFMDM
60
LFPGCVHLRK
70
VKFQAKLEHE
80
YIHNFKVLQA
90
AFKKMGVDKI
100
IPVEKLVKGK
110
FQDNFEFIQW
120
FKKFFDANYD
130
GKDYNPLLAR
140
QGQDVAPPPN
150
PGDQIFNKSK
160
KLIGTAVPQR
170
TSPTGPKNIQ
180
TSGRLSNVAP
190
PCILRKNPPS
200
ARNGGHETDT
210
QILELNQQLL
220
DLKLTVDGLE
230
KERDFYFSKL
240
RDIELICQEH
250
ESENSPVIAG
260
IISILYATEE
270
GFAPPEDDEI
280
EEHQQEDQDE
Y
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035371 |
microtubule plus-end |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:1905721 |
mitotic spindle astral microtubule end |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0051010 |
microtubule plus-end binding |
| Molecular Function |
GO:0043539 |
protein serine/threonine kinase activator activity |
| Molecular Function |
GO:0120283 |
protein serine/threonine kinase binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0031113 |
regulation of microtubule polymerization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.