Search Results
Overview
| Uniprot ID | H0V5U4 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 4B |
| Gene Name | Eif4b |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 511 | SPTSGGGKLAPAQPS |
| 551 | GLGDGGNKDHWKESD |
Function
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F
Protein Sequence
10
ASTKKKNKKG
20
KTISLTDFLA
30
EDGGTGGGTT
40
YVPKPVSWAD
50
ETDDLEGDVS
60
TTWHSNDDDV
70
YRAPPIDRSI
80
LPTAPRAARE
90
PNIDRSRLPK
100
SPPYTAFLGN
110
LPYEVTEDSI
120
KEFFRGLNIS
130
AVRLPREPSN
140
PDRLKGFGYA
150
EFEDLDSLLS
160
ALSLNEESLG
170
NRRIRVDVAD
180
QAQDKDRDDR
190
SFGRDRNRDS
200
DKTDTDWRAR
210
PATDSFDDYP
220
PRRGDDSFGD
230
KYRDRYDSDR
240
YRDGYRDRDG
250
YRDGPRRDMD
260
RYGGRDRYDD
270
RGSRDYDRGY
280
DSRIGSGRRA
290
FGSGYRRDDD
300
YRGGGDRYED
310
RYDRRDDRPW
320
GSRDDYSRDD
330
YRRDDRGPPQ
340
RPKLNLKPRS
350
TPKEDDSSAS
360
TSQSSRAASI
370
FGGAKPVDTA
380
AREREVEERL
390
QKEQEKLQRQ
400
LDEPKLERRP
410
RERHPSWRSE
420
ETQERERSRT
430
GSESSQTGTS
440
APSGRNARRR
450
ESEKSLENET
460
LSKEEDCHSP
470
TSKPPKPDQP
480
LKVMPAPPPK
490
ENAWVKRSSN
500
PSARSQSSDT
510
EHQSPTSGGG
520
KLAPAQPSEE
530
GPARKDENNG
540
MSTQKGQTGN
550
SIRGLGDGGN
560
KDHWKESDRK
570
DGKKDQDSRS
580
APEPKKLEEN
590
PASKFSSASK
600
YAALCMDGED
DNEGEDYTE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.