Search Results
Overview
| Uniprot ID | H0V5Z0 |
|---|---|
| Protein Name | Palmitoyl-protein thioesterase ABHD10, mitochondrial |
| Gene Name | ABHD10 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 204 | GTWTLPSKYHEDGVH |
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate
Protein Sequence
10
MASVGLAAWR
20
SCFIGGQATA
30
SFGHYHNLSA
40
PTLKSQRVPW
50
RFPVCRQKTS
60
FSFLNRPDLP
70
KLAYKRLNGK
80
SPGVIFIPGY
90
ISNMNGTKAL
100
AIEEFCKSLG
110
HAYIRFDYSG
120
VGNSEGNLEE
130
CTVGKWRKDI
140
LSIIDDIAVG
150
PQILVGSSLG
160
GWLMLHAAIA
170
RPEKVMALVG
180
VATAADTLVT
190
RFNQLPVEVK
200
KEAELKGTWT
210
LPSKYHEDGV
220
HHIRYSFIQE
230
AAHHCLLHSP
240
IPVNCPVRLL
250
HGLKDDVVPW
260
HTSMQVADRV
270
LSTDVDVILR
280
KDSDHRMKEK
290
ADLQLLTYTI
300
DDLIDKLSTI
VN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| Molecular Function | GO:0102390 | mycophenolic acid acyl-glucuronide esterase activity |
| Molecular Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.