Overview
| Uniprot ID | H0V6J1 |
|---|
| Protein Name | Eukaryotic translation initiation factor 3 subunit L |
|---|
| Gene Name | EIF3L |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 549 |
FFIRQIHKFEELNRT |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Protein Sequence
10
MSYPADDYES
20
EAAYDPYAYP
30
GDYDMHTGDP
40
KQDLAYERQY
50
EQQTYQVIPE
60
VIKNFIQYFH
70
KTVSDLIDQK
80
VYELQASRVS
90
SDVIDQKVYE
100
IQDIYENSWT
110
KLTERFFKNT
120
PWPEAEAIAP
130
QVGNDAVFLI
140
LYKELYYRHI
150
YAKVSGGPSL
160
EQRFESYYNY
170
CNLFNYILNA
180
DGPAPLELPN
190
QWLWDIIDEF
200
IYQFQSFSQY
210
RCKTAKKSEE
220
EIDFLRSNPK
230
IWNVHSVLNV
240
LHSLVDKSNI
250
NRQLEVYTSG
260
GDPESVAGEY
270
GRHSLYKMLG
280
YFSLVGLLRL
290
HSLLGDYYQA
300
IKVLENIELN
310
KKSMYSRVPE
320
CQVTTYYYVG
330
FAYLMMRRYQ
340
DAIRVFANIL
350
LYIQRTKSMF
360
QRTTYKYEMI
370
NKQNEQMHAL
380
LAIALTMYPM
390
RIDESIHLQL
400
REKYGDKMLR
410
MQKGDPQVYE
420
ELFSYSCPKF
430
LSPVVPNYDN
440
VHPNYHKEPF
450
LQQLKVFSDE
460
VQQQAQLSTI
470
RSFLKLYTTM
480
PVAKLAGFLD
490
LTEQEFCIQL
500
LVFKHKMKNL
510
VWTSGISALD
520
GEFQSASEVD
530
FYIDKDMIHI
540
ADTKVARRYG
550
DFFIRQIHKF
560
EELNRTLKKM
GQRP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016282 |
eukaryotic 43S preinitiation complex |
| Cellular Component |
GO:0033290 |
eukaryotic 48S preinitiation complex |
| Cellular Component |
GO:0005852 |
eukaryotic translation initiation factor 3 complex |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0001732 |
formation of cytoplasmic translation initiation complex |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.