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Overview

Uniprot ID	H0V6V0
Protein Name	Paired amphipathic helix protein Sin3a
Gene Name	SIN3A
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
1171	DKLECRFKLNSYKMV
444	PPVKKKPKLLSLKDS
449	KPKLLSLKDSSMADA

Function

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation

Protein Sequence

10 MKRRLEDQES 20 PVYAAQQRRI 30 PSGTEAFPHQ 40 HRVLAPAPPV 50 YEAVSETMQS 60 ATGIQYSVTP 70 SYQVSAVPQS 80 SGSHGPTIAA 90 VHSSHHHPTA 100 VQPHGSQVVQ 110 SHAHPAPPVA 120 PVQGQQQFQR 130 LKVEDALSYL 140 DQVKLQFGSQ 150 PQVYNDFLDI 160 MKEFKSQSID 170 TPGVISRVSQ 180 LFKGHPDLIM 190 GFNTFLPPGY 200 KIEVQTNDMV 210 NVTTPGQVHQ 220 IPTHGIQPQP 230 QPPPQHPSQP 240 SAQSAPATAQ 250 PAPQPPPAKV 260 SKPSQLQAHT 270 PASQQTPPVP 280 PYASPRSPPV 290 QPHTPVTISL 300 GTAPSLQNNQ 310 PVEFNHAINY 320 VNKIKNRFQG 330 QPDIYKAFLE 340 ILHTYQKEQR 350 NAKEAGGNYT 360 PALTEQEVYA 370 QVARLFKNQE 380 DLLSEFGQFL 390 PDANSSVLLS 400 KTTAEKVDSV 410 RNDHGGTVKK 420 PQLNNKPQRP 430 SQNGCQIRRH 440 SGTGTTPPVK 450 KKPKLLSLKD 460 SSMADASKHG 470 VGTESLFFDK 480 VRKALRSAEA 490 YENFLRCLVI 500 FNQEVISRAE 510 LVQLVSPFLG 520 KFPELFNWFK 530 NFLGYKESVH 540 LETFPKERAT 550 EGIAMEIDYA 560 SCKRLGSSYR 570 ALPKSYQQPK 580 CTGRTPLCKE 590 VLNDTWVSFP 600 SWSEDSTFVS 610 SKKTQYEEHI 620 YRCEDERFEL 630 DVVLETNLAT 640 IRVLEAIQKK 650 LSRLSAEEQA 660 KFRLDNTLGG 670 TSEVIHRKAL 680 QRIYADKAAD 690 IIDGLRKNPS 700 IAVPIVLKRL 710 KMKEEEWREA 720 QRGFNKVWRE 730 QNEKYYLKSL 740 DHQGINFKQN 750 DTKVLRSKSL 760 LNEIESIYDE 770 RQEQATEENA 780 GVPVGPHLSL 790 AYEDKQILED 800 AAALIIHHVK 810 RQTGIQKEDK 820 YKIKQIMHHF 830 IPDLLFAQRG 840 DLSDVEEEEE 850 EEMDVDEATG 860 AAKKHNGVGG 870 SPPKSKLLFS 880 NTTAQKLRGM 890 DEVYNLFYVN 900 NNWYIFMRLH 910 QILCLRLLRI 920 CSQAERQIEE 930 ENREREWERE 940 VLGIKRDKSD 950 SPAIQLRLKE 960 PMDVDVEDYY 970 PAFLDMVRSL 980 LDGNIDSSQY 990 EDSLREMFTI 1000 HAYIAFTMDK 1010 LIQSIVRQLQ 1020 HIVSDEICVQ 1030 VTDLYLAENN 1040 NGATGGQLNT 1050 QTSRSLLEST 1060 YQRKAEQLMS 1070 DENCFKLMFI 1080 QSQGQVQLTI 1090 ELLDTEEENS 1100 DDPVEAERWS 1110 DYVERYMNSD 1120 TTSPELREHL 1130 AQKPVFLPRN 1140 LRRIRKCQRG 1150 REQQEKEGKE 1160 GNSKKTMESV 1170 DSLDKLECRF 1180 KLNSYKMVYV 1190 IKSEDYMYRR 1200 TALLRAHQSH 1210 ERVSKRLHQR 1220 FQAWVDKWTK 1230 EHVPREMAAE 1240 TSKWLMGEGL 1250 EGLVPCTTTC 1260 DTETLHFVSI 1270 NKYRVKYGTV FKAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0070822	Sin3-type complex
Cellular Component	GO:0017053	transcription repressor complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0140416	transcription regulator inhibitor activity
Biological Process	GO:0002218	activation of innate immune response
Biological Process	GO:0021895	cerebral cortex neuron differentiation
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0042754	negative regulation of circadian rhythm
Biological Process	GO:1900181	negative regulation of protein localization to nucleus
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0002230	positive regulation of defense response to virus by host
Biological Process	GO:0045666	positive regulation of neuron differentiation
Biological Process	GO:0030516	regulation of axon extension
Biological Process	GO:0048511	rhythmic process
Biological Process	GO:0060337	type I interferon-mediated signaling pathway

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.