Search Results

Overview

Uniprot ID	H0V733
Protein Name	Alpha-1,4 glucan phosphorylase
Gene Name	PYGL
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
435	RIMALFPKDVDRLRR
861	ESSNEVNKTKGMAL*

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MGTSSVSRPV 20 PPAAMAKPLS 30 DQEKRRQISI 40 RGIVGVENVA 50 ELKKGFNRHL 60 HFTLVKDRNV 70 ATTRDYFFAL 80 AHTVRDHLVG 90 RWIRTQQHYY 100 DKCPKRVYYL 110 SLEFYMGRTL 120 QNTMINLGLQ 130 NACDEAIYQL 140 GLDMEELEEV 150 EEDAGLGNGG 160 LGRLAACFLD 170 SMATLGLAAY 180 GYGIRYEYGI 190 FNQKIRDGWQ 200 VEEADDWLRH 210 GNPWEKARPE 220 FMLPVHFYGR 230 VEHTPTGAKW 240 LDTQVVLALP 250 YDTPVPGYMN 260 NTVNTMRLWS 270 ARAPNDFNLR 280 DFNVGDYIQA 290 VLDRNLAENI 300 SRVLYPNDNF 310 FEGKELRLKQ 320 EYFVVAATLQ 330 DVIRRFKASK 340 FASSDNRGTV 350 FDAFPDQVAI 360 QLNDTHPALA 370 IPELMRIFVD 380 IEKLPWSKAW 390 DITKKTFAYT 400 NHTVLPEASE 410 RWPVDLVEKL 420 LPRHLQIIYE 430 INQKHLDRIM 440 ALFPKDVDRL 450 RRMSLIEEEG 460 GKRVNMAHLC 470 IVGCHAVNGV 480 AKIHSDIVKT 490 KVFKDFSELE 500 PDKFQNKTNG 510 ITPRRWLLLC 520 NPGLAELIAE 530 KIGEDYVKDL 540 SQLTKLHSFL 550 GDDVFLREMA 560 KVKQENKLKF 570 SQYLEKEYKV 580 KINPSSMFDV 590 QVKRIHEYKR 600 QLLNCLHVIT 610 MYNRIKKDPK 620 KLFVPRTVII 630 GGKAAPGYHM 640 AKMIIKLITS 650 VAEVVNNDPV 660 VGSKLKVIFL 670 ENYRVSLAEK 680 VIPATDLSEQ 690 ISTAGTEASG 700 TGNMKFMLNG 710 ALTIGTMDGA 720 NVEMAEEAGE 730 ENLFIFGMRV 740 DDVAALDKKG 750 YKAKEYYEAL 760 PELKLVIDQI 770 DNGFFSPEQP 780 DLFKDIINML 790 FHHDRFKVFA 800 DYEAYVKCQE 810 KVSQLYMNPK 820 AWNRMVLKNI 830 AASGKFSSDR 840 TIKEYARDIW 850 NMEPSDLKIS 860 LSTESSNEVN KTKGMAL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0016208	AMP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0032052	bile acid binding
Molecular Function	GO:0005536	D-glucose binding
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0002060	purine nucleobase binding
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0005980	glycogen catabolic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.