Search Results
Overview
| Uniprot ID | H0V787 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase Hakai |
| Gene Name | CBLL1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | VRRRIPIKLISKQAN |
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown
Protein Sequence
10
MDHTDNELQG
20
TNSSGSLGGL
30
DVRRRIPIKL
40
ISKQANKAKP
50
TPRTQRTINR
60
MPAKATAGDE
70
GFDYNEEELF
80
GNQRRFPEHL
90
FWDFKINILG
100
EKDDTPVHFC
110
DKCGLPIKIY
120
GRMIPCKHVF
130
CYDCAILHEK
140
KGDKMCPGCS
150
DPVQRIEQCT
160
RGSLFMCSIV
170
QGCKRTYLSQ
180
RDLQAHINHR
190
HMRAGKPVTR
200
TSLENVHPPI
210
APPPAEIPER
220
FIMPPDKHHM
230
SHIPPKQHIM
240
MPPPPLQHVP
250
HEHYNQPHED
260
IRAPPTELSM
270
APPPPRSVSQ
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0036396 | RNA N6-methyladenosine methyltransferase complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0030155 | regulation of cell adhesion |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.