Overview
| Uniprot ID | H0V7V0 |
|---|
| Protein Name | Porphobilinogen deaminase |
|---|
| Gene Name | HMBS |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 70 |
ILDTALSKIGEKSLF |
Function
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact
Protein Sequence
10
MSGNGDAAAT
20
AKENGSRMRV
30
IRVGTRKSQL
40
ARIQTDSVVA
50
ALKALYPGLQ
60
FEIVAMSTTG
70
DKILDTALSK
80
IGEKSLFTKE
90
LENALERNEV
100
DLVVHSLKDL
110
PTVLPPGFTI
120
GAICKRESPY
130
DAVVFHPKFV
140
GKTLETLPEK
150
SVVGTSSLRR
160
AAQLQRKFPH
170
LEFKSIRGNL
180
NTRLRKLDEQ
190
QEFSAIILAV
200
AGLQRLGWQN
210
RVGQILRPED
220
CMYAVGQGAL
230
GVEVRAKDQD
240
ILKLVGVLHD
250
HETVLCCIAE
260
RAFLRHLEGG
270
CSVPVAVHTV
280
MKDGQLYLTG
290
GVWSLDGSDS
300
MQETMQATIP
310
VPVQHEDGPE
320
DDPQLVGITA
330
RNIPRGAQLA
340
AENLGISLAN
350
LLLSKGAKDI
360
LEVARQLNDA
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0004418 |
hydroxymethylbilane synthase activity |
| Biological Process |
GO:0006784 |
heme A biosynthetic process |
| Biological Process |
GO:0006785 |
heme B biosynthetic process |
| Biological Process |
GO:0006782 |
protoporphyrinogen IX biosynthetic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.