Search Results

Overview

Uniprot ID	H0V7X8
Protein Name	Nuclear pore complex protein Nup98-Nup96
Gene Name	NUP98
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
1008	ISAIHSSKSRSLVGG

Function

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)

Protein Sequence

10 MFNKSFGAPF 20 GGGTSGFGTT 30 SSFGQNTGFG 40 TTTGGAFGTS 50 AFGSSTNTGG 60 LFGNSQTKPG 70 GLFGNNSFSQ 80 PATSTSTGFG 90 FGTSTGTSNS 100 LFGTASTGTG 110 LFSSQNNAFA 120 QNKPSGFGSS 130 FTAALTGTTI 140 KFNPPTGTDT 150 MVKAGVSTNI 160 STKHQCITAM 170 KEYESKSLEE 180 LRLEDYQANR 190 KGPQNQVGAG 200 TTTGLFGSSA 210 ATSSATGLFS 220 SSTTNSGFAY 230 GQNKTAFGTS 240 TTGFGTTPGG 250 LFGQPNQQTS 260 SLFNKPFGQA 270 TTTPNTGFSF 280 GNTSTLGQQS 290 TNTMGLFGVT 300 QASQPGSLFG 310 TATNTSTGTA 320 FGTGTGLFGQ 330 PSTGFGAVGS 340 TLFGNNKLTT 350 FGTSTTSAPS 360 FGTTSGGLFG 370 NKPTLTLGTN 380 TNTSNFGFGT 390 NTSGNSIFGS 400 KPAPGALGTG 410 LGTGFGTALG 420 AGQASLFGNN 430 QPKIGGPLGT 440 GAFGAPGFNT 450 TTATLGFGTP 460 QAPVALTDPN 470 ASAAQQAVLQ 480 QHLNSLTYSP 490 FGDSPLFRNP 500 MSDPKKKEER 510 LKPTNPAAQK 520 ALTTPTHYKL 530 TPRPATRVRP 540 KALQTAGTTK 550 SHLFDGLDDD 560 EPSLANGAFM 570 PKKSIKKLVL 580 KNLNNSNLFS 590 PVNRDSEDLA 600 SPSEYPENGE 610 RFSFLSKPVD 620 ENHQQDGDDD 630 SLVSHFYNNP 640 IAKPIPQTPE 650 NAGNKPNNSN 660 SVDDTIVALN 670 MRVALRNGLE 680 GSSEETSFHD 690 ESLQDDREEI 700 ENHVYPSHPA 710 GIVLTKVGYY 720 TIPSMDDLEI 730 TNEKGECIVS 740 DFTIGRKGYG 750 SIYFEGEVNL 760 TNLNLDDIVH 770 IRRKEVIVYL 780 DDDQKPPVGE 790 GLNRKAEVTL 800 DGVWPTDKTS 810 RCLIKSPDRL 820 ADINYEGRLE 830 AVSRKQGAQF 840 KEYRPETGSW 850 VFKVSHFSKY 860 GLQDSDEEEE 870 QRPSKTSTKK 880 LKTGTAPLSP 890 PGQAAPLQMA 900 LNGKPALPPQ 910 TQSPEVEQLG 920 RVVELDSDMV 930 DITQEPVLDS 940 MLEDSMPEDQ 950 EPVSASTHIA 960 SSLGINPHVL 970 QIMKASLLAD 980 EEDVDIMDQH 990 FSHLPSKGDT 1000 SQEICSPRLP 1010 ISAIHSSKSR 1020 SLVGGLLQSK 1030 FTSGAFLSPS 1040 ASVQECRTPR 1050 ASSLMNIPST 1060 SPWSVPPPLA 1070 TVFTVPSPAP 1080 EVQLKTVGTR 1090 RHPGLVPLEK 1100 SVTYGKGNLL 1110 MDMALFMGRS 1120 FRVGWGPNWT 1130 LANSGERLSD 1140 SLELENHQIA 1150 DCMEYGFLPN 1160 PMAVKSLTES 1170 PFKVHLEKLN 1180 LRQRKLDEDL 1190 QLFQTPLELK 1200 LKHSTVNVDE 1210 MCPFITPNVG 1220 VAVIHDYVHW 1230 VKEVSRDLLE 1240 AQIVKPWSLT 1250 WTLCEALWGH 1260 LKDLDSQPGE 1270 PSAYTQILER 1280 RRAFSHWLSN 1290 STTALIEEEV 1300 STRKDNPIEA 1310 VFSYLTGNRI 1320 SAACSLAQQS 1330 GDHRLALLLS 1340 QLVGSHSLQN 1350 LLSMQLADWH 1360 HLQADCFIQK 1370 ERLRVYALLA 1380 GKPVWQISKQ 1390 MQINVCAQLD 1400 WKRSLAVHLW 1410 YLLPPTASIS 1420 RALSKYEEAF 1430 QDTSDGDKYA 1440 CPPLPSYLEG 1450 SGCVLQKEND 1460 SEIPLRDVCF 1470 HLLKLYSNRK 1480 YGLDQLLEPR 1490 SITADPLDYR 1500 LSWHLWEVLR 1510 TLNYNHLEKQ 1520 SEGVLHASYA 1530 AQLESEGLWE 1540 WAIFVFLHID 1550 NSSIREKAVR 1560 ELLTRHCQLL 1570 ETPESWAKET 1580 FLTQKLCVPA 1590 EWIHEAKAVR 1600 AHMESDPHLE 1610 ALYLFKAGHW 1620 NHCHKLVIRH 1630 LASDAIINEN 1640 YDYLKGFLED 1650 LAPPERSSLI 1660 QDWETSGLVY 1670 LDYIQIIEIL 1680 RRIQQEECSS 1690 YELEQLNTKV 1700 TSLCSRIEQI 1710 QCYSAKDRLA 1720 QSDMAKRVAN 1730 LLRVVLSLRH 1740 TSDVTSDATP 1750 DPQRVPLRLL 1760 APHIGRLPMP 1770 EDYALEEMSS 1780 LTQSYLRELT VGSQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0044614	nuclear pore cytoplasmic filaments
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0031080	nuclear pore outer ring
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0140693	molecular condensate scaffold activity
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:1990841	promoter-specific chromatin binding
Molecular Function	GO:0008236	serine-type peptidase activity
Molecular Function	GO:0017056	structural constituent of nuclear pore
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome
Biological Process	GO:0000973	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0034398	telomere tethering at nuclear periphery

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.