Overview
| Uniprot ID | H0V804 |
|---|
| Protein Name | Aldose 1-epimerase |
|---|
| Gene Name | GALM |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 93 |
GTFTLDGKKYQLPIN |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
MVSVTRNVFG
20
ELPLGGGTVE
30
KFQLQSDQLR
40
VDIISWGCTI
50
TALEVKDRQG
60
KASDVVLGFA
70
ELEGYLQKQP
80
YFGAVVGRVA
90
NRIAKGTFTL
100
DGKKYQLPIN
110
REPNSLHGGL
120
RGFDKVLWTP
130
QVLSNGVEFS
140
RVSPDGEEGY
150
PGELKVWVTY
160
TLDGGELVVN
170
YRAQASRATP
180
VNLTNHSYFN
190
LAGQGSPNIY
200
DHEVTIEADT
210
FLPVDETLIP
220
TGDIAPVQGT
230
AFDLRKPVVL
240
GTHLQDFHID
250
GFDHNFCLKR
260
SKEKHFCARV
270
YHGGSGRVLE
280
VYTTQPGVQF
290
YTGNFLDGTL
300
KGKGGAVYPK
310
HSGFCLETQN
320
WPDAVNQPHF
330
PPVLLRPGEE
340
YDHTTWFKFS
VA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0033499 |
galactose catabolic process via UDP-galactose, Leloir pathway |
| Biological Process |
GO:0006006 |
glucose metabolic process |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.