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Overview

Uniprot IDH0V8R3
Protein NameParkinson disease protein 7 homolog
Gene NamePARK7
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
130 VTTHPLAKDKMMNGN
41 TVAGLTGKDPVQCSR

Function

No function data available.

Protein Sequence

10 MASKRALVIL 20 AKGAEEMETV 30 IPVDVMRRAG 40 IKVTVAGLTG 50 KDPVQCSRDV 60 VICPDTSLEE 70 AKKEGPYDVV 80 VLPGGNLGAQ 90 NLSESPAVKE 100 ILKEQEGRKG 110 LIAAICAGPT 120 ALLAHEIGFG 130 SKVTTHPLAK 140 DKMMNGNHYS 150 YSESRVERDG 160 QVLTSRGPGT 170 SFEFALAIVE 180 ALSGKEVAQQ VKAPLVLRD

Gene Ontology

Classification GO ID Description
Biological Process GO:0061691 detoxification of hydrogen peroxide
Cellular Component GO:0044297 cell body
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016605 PML body
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:1903135 cupric ion binding
Molecular Function GO:1903136 cuprous ion binding
Molecular Function GO:0019955 cytokine binding
Molecular Function GO:1990422 glyoxalase (glycolic acid-forming) activity
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0036478 L-dopa decarboxylase activator activity
Molecular Function GO:0045340 mercury ion binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0050681 nuclear androgen receptor binding
Molecular Function GO:0019826 oxygen sensor activity
Molecular Function GO:0008233 peptidase activity
Molecular Function GO:0030414 peptidase inhibitor activity
Molecular Function GO:0051920 peroxiredoxin activity
Molecular Function GO:0036524 protein deglycase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0030546 signaling receptor activator activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0044388 small protein activating enzyme binding
Molecular Function GO:0016532 superoxide dismutase copper chaperone activity
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0036470 tyrosine 3-monooxygenase activator activity
Molecular Function GO:0044390 ubiquitin-like protein conjugating enzyme binding
Molecular Function GO:0055105 ubiquitin-protein transferase inhibitor activity
Molecular Function GO:1990381 ubiquitin-specific protease binding
Biological Process GO:0030521 androgen receptor signaling pathway
Biological Process GO:0006914 autophagy
Biological Process GO:0036471 cellular response to glyoxal
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0070994 detection of oxidative stress
Biological Process GO:0010273 detoxification of copper ion
Biological Process GO:0050787 detoxification of mercury ion
Biological Process GO:0006281 DNA repair
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0106046 guanine deglycation, glyoxal removal
Biological Process GO:0106045 guanine deglycation, methylglyoxal removal
Biological Process GO:0006954 inflammatory response
Biological Process GO:0030073 insulin secretion
Biological Process GO:0019249 lactate biosynthetic process
Biological Process GO:0061727 methylglyoxal catabolic process to lactate
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1903073 negative regulation of death-inducing signaling complex assembly
Biological Process GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0046826 negative regulation of protein export from nucleus
Biological Process GO:1903094 negative regulation of protein K48-linked deubiquitination
Biological Process GO:0033234 negative regulation of protein sumoylation
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Biological Process GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway
Biological Process GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
Biological Process GO:1903181 positive regulation of dopamine biosynthetic process
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:1900182 positive regulation of protein localization to nucleus
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0030091 protein repair
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006508 proteolysis
Biological Process GO:0060765 regulation of androgen receptor signaling pathway
Biological Process GO:0051881 regulation of mitochondrial membrane potential
Biological Process GO:1900242 regulation of synaptic vesicle endocytosis
Biological Process GO:0019430 removal of superoxide radicals
Biological Process GO:0007338 single fertilization

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.