Search Results
Overview
| Uniprot ID | H0V949 |
|---|---|
| Protein Name | HBS1-like protein |
| Gene Name | HBS1L |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | GRVMSTGKIPKGKSV |
Function
GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway
Protein Sequence
10
MARHRNVRGY
20
NYDEDFEDDD
30
FYGQSVEDDY
40
CISPSTAAQF
50
IYSQRDKPSV
60
CYDDLKDSAN
70
SVSDQQLSGL
80
DQARLYSCLD
90
HMREVLGDAV
100
PDEILIEAVM
110
KNKFDVQKAL
120
SFVLERDNGQ
130
NLKDKSGRVM
140
STGKIPKGKS
150
VESQSSRSES
160
EIVPKVAKMT
170
VSGKKQTMGF
180
EVPGVAAEEN
190
GHVIQTPLKG
200
PVDEDTAIAS
210
SDILETVTSS
220
ALPSPLQSDR
230
RADSGRRYVG
240
KQLHQFVPIG
250
MVLAPKLSLL
260
SNHLMFRLRG
270
VTMDVGMTKF
280
ETTTKVITLM
290
DAPGHKDFIP
300
NMITGAAQAD
310
VAVLVVDASR
320
GEFEAGFETG
330
GQTREHGLLV
340
RSLGVTQLAV
350
AVNKMDQVNW
360
QQERFQEITG
370
KLGHFLKQAG
380
FKESDVAFIP
390
TSGLSGENLI
400
TRSQLNELTK
410
WYKGLCLLEQ
420
IDSFKPPQRS
430
VDKPFRLCVS
440
DVFKDQGSGF
450
CVTGKIEAGY
460
IQIGDRLLAM
470
PPNETCTARG
480
ITLHDEPVDW
490
AAAGDHVSLN
500
LVGMDIIKIN
510
VGCIFCGPKE
520
PIKACTRFRA
530
RILIFNIEIP
540
ITKGFPVLLH
550
YQTVSEPAVI
560
KRLISVLSKS
570
SGEVTKKKPK
580
LLTKGQNALV
590
ELQTQRPVAL
600
ELYKDFKELG
610
RFMLRYSGST
620
IAAGVVTEVF
CND
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0072344 | rescue of stalled cytosolic ribosome |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:1990533 | Dom34-Hbs1 complex |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0003746 | translation elongation factor activity |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.