Overview
| Uniprot ID | H0V9E0 |
|---|
| Protein Name | RING-type E3 ubiquitin-protein ligase PPIL2 |
|---|
| Gene Name | PPIL2 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 232 |
MKAPEKKKVDQLNAA |
| 507 |
STAAPVAKKKSSWGF |
Function
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Protein Sequence
10
MGKRQHQKDK
20
MYITCAEYTH
30
FYGGKKPDVP
40
QTNFRRLPFD
50
HCSLSLQPFA
60
YPVCTPEGVV
70
FDLLNIVPWL
80
KKYGTNPSNG
90
EKLDGRSLIK
100
LNFAKNSEGK
110
YHCPVLFTVF
120
TNNTYIVAIK
130
TTGNVYAYEA
140
VEQLNIKAKN
150
FRDLLTDEPF
160
SRQDIITLQD
170
PTNLDKFNVS
180
NFFHVKNNMK
190
IIDPDEEKAK
200
QDPSYYLKNT
210
NTETRETLQE
220
LYKEFKGDEI
230
LAATMKAPEK
240
KKVDQLNAAH
250
YSTGKVSASF
260
TSTAMVPETT
270
HEAAAIDEDV
280
LRYQFVKKKG
290
YVRLHTNKGD
300
LNLELHCDLT
310
PKTCENFIKL
320
CKKHYYDGTI
330
FHRSIRNFVI
340
QGGDPTGTGT
350
GGESYWGKTF
360
KDEFRPNLSH
370
TGRGILSMAN
380
SGPNTNKSQF
390
FITFRSCAYL
400
DKKHTIFGRV
410
VGGFDTLTAM
420
ENVESDPKTD
430
RPKEEIRIDA
440
TTVFVDPYEE
450
ADAQIAQERK
460
TKPEVTPEDK
470
MKNSQPQPGS
480
QGPQTYRQGV
490
GKYINPAATK
500
RVAEEEPSTS
510
TAAPVAKKKS
520
SWGFGDFSSW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function |
GO:0034450 |
ubiquitin-ubiquitin ligase activity |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.