Search Results
Overview
| Uniprot ID | H0VAM9 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha |
| Gene Name | CAPZA2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 97 | PKNRICFKFDHLRKE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
MADLEEQLSD
20
EEKVRIAAKF
30
IIHAPPGEFN
40
EVFNDVRLLL
50
NNDNLLREGA
60
AHAFAQYNLD
70
QFTPVKIEGY
80
EDQVLITEHG
90
DLGNGKFLDP
100
KNRICFKFDH
110
LRKEATDPRP
120
YEAENAIESW
130
RTSVETALRA
140
YVKEHYPNGV
150
CTVYGKKIDG
160
QQTIIACIES
170
HQFQAKNFWN
180
GRWRSEWKFT
190
ITPSTTQVVG
200
ILKIQVHYYE
210
DGNVQLVSHK
220
DILDSLTVSN
230
EAQTAKEFIK
240
IVEAAENEYQ
250
TAISENYQTM
260
SDTTFKALRR
270
QLPVTRTKID
WNKILSYKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0030863 | cortical cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.