Search Results
Overview
| Uniprot ID | H0VAT3 |
|---|---|
| Protein Name | Histone deacetylase 1 |
| Gene Name | HDAC1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 412 | ISICSSDKRIACEEE |
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins
Protein Sequence
10
MAQTQGTRRK
20
VCYYYDGDVG
30
NYYYGQGHPM
40
KPHRIRMTHN
50
LLLNYGLYRK
60
MEIYRPHKAN
70
AEEMTKYHSD
80
DYIKFLRSIR
90
PDNMSEYSKQ
100
MQRFNVGEDC
110
PVFDGLFEFC
120
QLSTGGSVAS
130
AVKLNKQQTD
140
IAVNWAGGLH
150
HAKKSEASGF
160
CYVNDIVLAI
170
LELLKYHQRV
180
LYIDIDIHHG
190
DGVEEAFYTT
200
DRVMTVSFHK
210
YGEYFPGTGD
220
LRDIGAGKGK
230
YYAVNYPLRD
240
GIDDESYEAI
250
FKPVMSKVME
260
MFQPSAVVLQ
270
CGSDSLSGDR
280
LGCFNLTIKG
290
HAKCVEFVKS
300
FNLPMLMLGG
310
GGYTIRNVAR
320
CWTYETAVAL
330
DTEIPNELPY
340
NDYFEYFGPD
350
FKLHISPSNM
360
TNQNTNEYLE
370
KIKQRLFENL
380
RMLPHAPGVQ
390
MQAIPEDAIP
400
EESGDEDEED
410
PDKRISICSS
420
DKRIACEEEF
430
SDSDEEGEGG
440
RKNSSNYKKA
450
KRVKTEDEKE
460
KDPEEKKEVT
470
EEEKTKEEKP
480
EAKGVKEEVK
LT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0016581 | NuRD complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0070822 | Sin3-type complex |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0141221 | histone deacetylase activity, hydrolytic mechanism |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0160009 | histone decrotonylase activity |
| Molecular Function | GO:0035851 | Krueppel-associated box domain binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0160216 | protein lysine delactylase activity |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Biological Process | GO:0032922 | circadian regulation of gene expression |
| Biological Process | GO:0006346 | DNA methylation-dependent constitutive heterochromatin formation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0042733 | embryonic digit morphogenesis |
| Biological Process | GO:0009913 | epidermal cell differentiation |
| Biological Process | GO:0061029 | eyelid development in camera-type eye |
| Biological Process | GO:0061198 | fungiform papilla formation |
| Biological Process | GO:0060789 | hair follicle placode formation |
| Biological Process | GO:0043922 | host-mediated suppression of viral transcription |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0042475 | odontogenesis of dentin-containing tooth |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.