Search Results
Overview
| Uniprot ID | H0VBD5 |
|---|---|
| Protein Name | Fascin |
| Gene Name | FSCN1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 241 | SGPSGTLKAGKATKV |
| 399 | HGFIGCRKVTGTLDA |
| 41 | NASASSLKKKQIWTL |
| 471 | KVGGRYLKGDHAGVL |
| 74 | GRYLAADKDGNVTCE |
Function
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF
Protein Sequence
10
MTANGTAEAV
20
QIQFGLINCS
30
NKYLTAEAFG
40
FKVNASASSL
50
KKKQIWTLEQ
60
PPDEAGSAAV
70
CLRSHLGRYL
80
AADKDGNVTC
90
EREVPGPDCR
100
FLIVAHDDGR
110
WSLQSEAHRR
120
YFGGTEDRLS
130
CFAQTVSPAE
140
KWSVHIAMHP
150
QVNIYSLTRK
160
RYAHLSARPA
170
DEIAVDRDVP
180
WGVDSLITLA
190
FQDQRYSVQT
200
ADHRFLRHDG
210
RLVARPEPAT
220
GYTLEFRSGK
230
VAFRDFEGRY
240
LAPSGPSGTL
250
KAGKATKVGK
260
DELFALEQSC
270
AQVVLQAANE
280
RNVSTRQGMD
290
LSANQDEETD
300
QETFQLEIDR
310
DTRKCAFRTY
320
TGKYWTLTAT
330
GGVQSTASTK
340
NASCYFDIEW
350
RDRRITLRAS
360
NGKFVTAKKN
370
GQLAASVETA
380
GDAELFLMKL
390
INRPIIVFRG
400
EHGFIGCRKV
410
TGTLDANRSS
420
YDVFQLEFND
430
GAYNIKDSTG
440
KYWMVGNDSS
450
VTSSSDTPVD
460
FFFEFCDYNK
470
VAIKVGGRYL
480
KGDHAGVLKA
490
CAETVDPASL
WEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0044393 | microspike |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007043 | cell-cell junction assembly |
| Biological Process | GO:0035089 | establishment of apical/basal cell polarity |
| Biological Process | GO:0030035 | microspike assembly |
| Biological Process | GO:0030046 | parallel actin filament bundle assembly |
| Biological Process | GO:0090091 | positive regulation of extracellular matrix disassembly |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0071803 | positive regulation of podosome assembly |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0032534 | regulation of microvillus assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.