Search Results

Overview

Uniprot ID	H0VBH3
Protein Name	U4/U6 small nuclear ribonucleoprotein Prp3
Gene Name	PRPF3
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
282	THRMPTLKANIRAVK

Function

Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)

Protein Sequence

10 MALSKRELDE 20 LKPWIEKTVK 30 RVLGFSEPTV 40 VTAALNCVGK 50 GMDKKKAADH 60 LKPFLDESTL 70 RFVDKLFEAV 80 EEGRSSRHSK 90 SSSDRSRKRE 100 LKEVFGDDSE 110 ISKESSGVKK 120 RRIPRFEEVE 130 EEPEVIPGPP 140 SESPGMLTKL 150 QIKQMMEAAT 160 RQIEERKKQL 170 SFISPPAPQP 180 KTPSSSQPER 190 LPIGNTIQPS 200 QAATFMNDAI 210 EKARKAAELQ 220 ARIQAQLALK 230 PGLIGNANMV 240 GLANLHAMGI 250 APPKVELKDQ 260 TKPTPLILDE 270 QGRTVDATGK 280 EIELTHRMPT 290 LKANIRAVKR 300 EQFKQQLKEK 310 PSEDMESNTF 320 FDPRVSIAPS 330 QRQRRTFKFH 340 DKGKFEKIAQ 350 RLRTKAQLEK 360 LQAEISQAAR 370 KTGIHASTRL 380 ALIAPKKELK 390 EGDIPEIEWW 400 DSYIIPNGFD 410 LTEENPKRED 420 YFGITNLVEH 430 PAQLNPPVDN 440 DTPVTLGVYL 450 TKKEQKKLRR 460 QTRREAQKEL 470 QEKVRLGLMP 480 PPEPKVRISN 490 LMRVLGTEAV 500 QDPTKVEAHV 510 RAQMAKRQKA 520 HEEANAARKL 530 TAEQRKVKKI 540 KKLKEDISQG 550 VHISVYRVRN 560 LSNPAKKFKI 570 EANAGQLYLT 580 GVVVLHKDVN 590 VVVVEGGPKA 600 QKKFKRLMLH 610 RIKWDEQTSN 620 TKGDDDEESD 630 EEAVKKTNKC 640 VLVWEGTAKD 650 RSFGEMKFKQ 660 CPTENMAREH 670 FKKHGAEHYW 680 DLALSESVLE STD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015030	Cajal body
Cellular Component	GO:0071005	U2-type precatalytic spliceosome
Cellular Component	GO:0046540	U4/U6 x U5 tri-snRNP complex
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.