Overview
| Uniprot ID | H0VBM9 |
|---|
| Protein Name | ADP-ribosylation factor 6 |
|---|
| Gene Name | ARF6 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 69 |
WDVGGQDKIRPLWRH |
Function
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes
Protein Sequence
10
MGKVLSKIFG
20
NKEMRILMLG
30
LDAAGKTTIL
40
YKLKLGQSVT
50
TIPTVGFNVE
60
TVTYKNVKFN
70
VWDVGGQDKI
80
RPLWRHYYTG
90
TQGLIFVVDC
100
ADRDRIDEAR
110
QELHRIINDR
120
EMRDAIILIF
130
ANKQDLPDAM
140
KPHEIQEKLG
150
LTRIRDRNWY
160
VQPSCATSGD
170
GLYEGLTWLT
SNYKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0032154 |
cleavage furrow |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0030139 |
endocytic vesicle |
| Cellular Component |
GO:0031527 |
filopodium membrane |
| Cellular Component |
GO:0090543 |
Flemming body |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0001726 |
ruffle |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0035591 |
signaling adaptor activity |
| Molecular Function |
GO:0031996 |
thioesterase binding |
| Biological Process |
GO:0030866 |
cortical actin cytoskeleton organization |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:2000009 |
negative regulation of protein localization to cell surface |
| Biological Process |
GO:0030838 |
positive regulation of actin filament polymerization |
| Biological Process |
GO:0120183 |
positive regulation of focal adhesion disassembly |
| Biological Process |
GO:0051549 |
positive regulation of keratinocyte migration |
| Biological Process |
GO:1903438 |
positive regulation of mitotic cytokinetic process |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
| Biological Process |
GO:0050714 |
positive regulation of protein secretion |
| Biological Process |
GO:0034394 |
protein localization to cell surface |
| Biological Process |
GO:1905345 |
protein localization to cleavage furrow |
| Biological Process |
GO:0036010 |
protein localization to endosome |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0060998 |
regulation of dendritic spine development |
| Biological Process |
GO:0051489 |
regulation of filopodium assembly |
| Biological Process |
GO:0035020 |
regulation of Rac protein signal transduction |
| Biological Process |
GO:0097178 |
ruffle assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.