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Overview

Uniprot IDH0VBQ8
Protein NameNipped-B protein
Gene NameNIPBL
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
529 KSDPEVSKSEVKQNE

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others

Protein Sequence

10 ELKDNLGSDD 20 PEGDIPVLLQ 30 AVLARSPNVF 40 REKSMQNRYV 50 QSGMMMSQYK 60 LSQNSMHSSP 70 ASSNYQQTTI 80 SHSPSSRFVP 90 PPTSTGNRFI 100 PQQNSPVPSP 110 YAPQSPAGYM 120 PYSHPSSYTT 130 HPQMQQASVS 140 SPIVAGGLRN 150 MHDNKVSGPL 160 SGSSANHHTD 170 NPRHGSSDDY 180 LHMVHRLSSD 190 DGDSSAMRNA 200 ASFPLRSPQP 210 VSSEGVNKRS 220 RPPLILQSQP 230 LPCSSPRDVP 240 PDILLDSPER 250 KQKKQKKMKL 260 GKDEKDQSEK 270 AAMYDIISSP 280 SKDSTKLTLR 290 LSRVRSSDMD 300 QQEDMLSGME 310 NSNVSENDIP 320 FNVQYPGQTS 330 KTPITPQDVN 340 RPLNAAQCLS 350 QQEQTAFLPA 360 NQVPVLQQNT 370 LVATKQPQTS 380 VVQNQQQVSQ 390 QGPIYDEVEL 400 DALAEIERIE 410 RESAIERERF 420 SKEVQDKDKP 430 LKKRKQDSYP 440 QEAGGATGGN 450 RPASQDTGST 460 GNGSRPALMV 470 SIDLHQAGRV 480 DSQASVTQDS 490 DSLKKPEEIK 500 QCNDAPISIL 510 QEDIIGSLKS 520 TPENHPETPK 530 KKSDPEVSKS 540 EVKQNESRLS 550 ESKHNENRLV 560 EMKSSESKLE 570 TKIETPTEEL 580 KQNENRTTEP 590 KQNESTIVES 600 KQNENRLSDT 610 KPNDNKQNSG 620 RSETTKSRPE 630 TPKQKGESRP 640 ETPKQKSDGR 650 PETPKQKGDG 660 RPETPKQKNE 670 GRPETPKQKN 680 EGRPETPKHR 690 HENRRDSGKL 700 SAEKKPEMSK 710 HKQDMKSDSP 720 RLKSERAESL 730 KQRPDGRSVS 740 ESLRRDHDSK 750 QKSDDRGESE 760 RHRGDQSRVR 770 RPETLRSSSR 780 NEHGIKSEGS 790 KTDKLERKHR 800 HESGDSRERP 810 SSGEQKSRPD 820 SPRVKQGDSN 830 KSRPDKPGFK 840 SPNSKDDKRT 850 EGNRNKVDSN 860 KMHPDNKAEF 870 PSYLLGGRSG 880 ALKNFVIPKI 890 KRDKDGNITQ 900 ETKKMDLKGE 910 QKDKVEKLGL 920 VEDLNKGAKP 930 VVVLQKLSLD 940 DVQKLIKDRE 950 DKSRSSLKSI 960 KNKSSKSNKG 970 SIDQSVLKEL 980 PPELLAEIES 990 TMPLCERVKM 1000 NKRKRSTVNE 1010 KPKYAEISSD 1020 EDNDSDEAFE 1030 SSRKRHKKDD 1040 DKAWEYEERD 1050 RRSSGDHRRS 1060 GHSHEGRRSS 1070 GGGRYRNRSP 1080 SDSDMEDYSP 1090 PPSLSEVARK 1100 MKKKEKQKKR 1110 KAYEPKLTPE 1120 EMMDSSTFKR 1130 FTASIENILD 1140 NLEDLDFTAF 1150 GDDDEIPQEL 1160 LLGKHQLNEL 1170 GSESAKIKAM 1180 GIMDKLSTDK 1190 TVKVLNILEK 1200 NIQDGSKLST 1210 LLNHNNDTEE 1220 EERLWRDLIM 1230 ERVTKSADAC 1240 LTTINIMTSP 1250 NMPKAVYIED 1260 VIERVIQYTK 1270 FHLQNTLYPQ 1280 YDPVYRLDPH 1290 GGGLLSSKAK 1300 RAKCSTHKQR 1310 VIVMLYNKVC 1320 DIVSSLSELL 1330 EIQLLTDTTI 1340 LQVSSMGITP 1350 FFVENVSELQ 1360 LCAIKLVTAV 1370 FSRYEKHRQL 1380 ILEEIFTSLA 1390 RLPTSKRSLR 1400 NFRLNSSDMD 1410 GEPMYIQMVT 1420 ALVLQLIQCV 1430 VHLPSSEKDS 1440 NSEEDSNKKV 1450 DQDVVITNSY 1460 ETAMRTAQNF 1470 LSIFLKKCGS 1480 KQGEEDYRPL 1490 FENFVQDLLS 1500 TVNKPEWPAA 1510 ELLLSLLGRL 1520 LVHQFSNKST 1530 EMALRVASLD 1540 YLGTVAARLR 1550 KDAVTSKMDQ 1560 GSIERILKQV 1570 SGGEDEIQQL 1580 QKALLDYLDE 1590 NTETDPSLVF 1600 SRKFYIAQWF 1610 RDTTLETEKA 1620 MKSQKDEESS 1630 EGTHHAKEVE 1640 TTGQIMHRAE 1650 NRKKFLRSII 1660 KTTPSQFSTL 1670 KMNSDTVDYD 1680 DACLIVRYLA 1690 SMRPFAQSFD 1700 IYLTQILRVL 1710 GENAIAVRTK 1720 AMKCLSEVVA 1730 VDPSILARLD 1740 MQRGVHGRLM 1750 DNSTSVREAA 1760 VELLGRFVLC 1770 RPQLAEQYYD 1780 MLIERILDTG 1790 ISVRKRVIKI 1800 LRDICIEQPT 1810 FPKITEMCVK 1820 MIRRVNDEEG 1830 IKKLVNETFQ 1840 KLWFTPTPHN 1850 DKEAMTRKIL 1860 NITDVVRMQK 1870 PVLGPLWLNV 1880 LLFMKSEEDS 1890 SYKPVKKACT 1900 QLVDNLVEHI 1910 LKYEESLADS 1920 DNKGVNSGRL 1930 VACITTLFLF 1940 SKIRPQLMVK 1950 HAMTMQPYLT 1960 TKCSVSIETA 1970 NDSWLSCNVA 1980 KILELVASSG 1990 NFPCHIEEDL 2000 MKLIIKYGMT 2010 VVQHCVSCLG 2020 AVVNKVTQNF 2030 KFVWACFNRY 2040 YGAISKLKSQ 2050 HQEDPNNTSL 2060 LTNKPALLRS 2070 LFTVGALCRH 2080 FDFDLEDFKG 2090 NSKVNIKDKV 2100 LELLMYFTKH 2110 SDEEVQTKAI 2120 IGLGFAFIQH 2130 PSLMFEQEVK 2140 NLYNNILSDK 2150 NSSVNLKIQV 2160 LKNLQTYLQE 2170 EDTRMQQADR 2180 DWKKVAKQED 2190 LKEMGDVSSG 2200 MSSSIMQLYL 2210 KQVLEAFFHT 2220 QSSVRHFALN 2230 VIALTLNQGL 2240 IHPVQCVPYL 2250 IAMGTDPEPA 2260 MRNKADQQLV 2270 EIDKKYAGFI 2280 HMKAVAGMKM 2290 SYQVQQAINT 2300 CLKDPVRGFR 2310 QDESSSALCS 2320 HLYSMIRGNR 2330 QHRRAFLISL 2340 LNLFDDTAKT 2350 EVTMLLYIAD 2360 NLACFPYQTQ 2370 EEPLFIMHHI 2380 DITLSVSGSN 2390 LLQSFKESMV 2400 KDKRKERKSS 2410 PSKENESSES 2420 EEEVSRPRKS 2430 RKRVDSDSDS 2440 DSEDDINSVM 2450 KCLPENSAPL 2460 IEFANVSQGI 2470 LLLLMLKQHL 2480 KNLCGFSDSK 2490 IQKYSPSESA 2500 KVYDKAINRK 2510 TGVHFHPKQT 2520 LDFLRSDMAN 2530 SKITEEVKRS 2540 IVKQYLDFKL 2550 LMEHLDPDEE 2560 EEEGEVSAST 2570 NARNKAITSL 2580 LGGGSPKNNT 2590 AAETEDDESD 2600 GEDRGGGTSG 2610 SLRRSKRNSD 2620 STELAAQMNE 2630 SVDVMDVIAI 2640 CCPKYKDRPQ 2650 IARVVQKTSS 2660 GFSVQWMAGS 2670 YSGSWTEAKR 2680 RDGRKLVPWV 2690 DTIKESDIIY 2700 KKIALTSANK 2710 LTNKVVQTLR 2720 SLYAAKDGTS S

Gene Ontology

Classification GO ID Description
Molecular Function GO:0042826 histone deacetylase binding
Cellular Component GO:0000785 chromatin
Cellular Component GO:0032039 integrator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0090694 Scc2-Scc4 cohesin loading complex
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0061775 cohesin loader activity
Molecular Function GO:0036033 mediator complex binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0007420 brain development
Biological Process GO:0071481 cellular response to X-ray
Biological Process GO:0140588 chromatin looping
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0050890 cognition
Biological Process GO:0048589 developmental growth
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0042471 ear morphogenesis
Biological Process GO:0048557 embryonic digestive tract morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0034087 establishment of mitotic sister chromatid cohesion
Biological Process GO:0071169 establishment of protein localization to chromatin
Biological Process GO:0035261 external genitalia morphogenesis
Biological Process GO:0048592 eye morphogenesis
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0061010 gallbladder development
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0034088 maintenance of mitotic sister chromatid cohesion
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:2001224 positive regulation of neuron migration
Biological Process GO:0048638 regulation of developmental growth
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0042634 regulation of hair cycle
Biological Process GO:1990414 replication-born double-strand break repair via sister chromatid exchange
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0061038 uterus morphogenesis

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.