Overview
| Uniprot ID | H0VBS1 |
|---|
| Protein Name | Protein disulfide-isomerase |
|---|
| Gene Name | PDIA3 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 129 |
DGIVSHLKKQAGPAS |
Function
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Protein Sequence
10
MRSYGLALFP
20
GVALILATAR
30
LAAASDVLEL
40
TDDNFESRVS
50
DTGSAGLMLV
60
EFFAPWCGHC
70
KRLAPEYEAA
80
ATRLKGIVPL
90
AKVDCTANTN
100
TCNKYGVTGY
110
PTLKIFRDGE
120
EAGAYDGPRT
130
ADGIVSHLKK
140
QAGPASVPLK
150
TEEEFKKFIS
160
DKDASVVGFF
170
RDLFTEAHSE
180
FLKAASNLRD
190
NYRFAHTNVE
200
SLVKEYDDNG
210
EGITLFRPSH
220
LANKFEDKTV
230
AYTEQKMTSG
240
KIKKFIQENI
250
FGICPHMTED
260
NKDLIQGKDL
270
LIAYYDVDYE
280
KNAKGSNYWR
290
NRVMMVAKKF
300
LDAGHKLNFA
310
VASRKTFSHE
320
LSDFGLESTA
330
GEIPVVAIRT
340
AKGEKFVMQE
350
EFSRDGKALE
360
RFLQGYFDGN
370
LKRYLKSEPV
380
PESNDGPVKV
390
VVAENFDEIV
400
NNEDKDVLIE
410
FYAPWCGHCK
420
NLEPKYKELG
430
EKLSKDPNIV
440
IAKMDATAND
450
VPSPYEVRGF
460
PTIYFSPAHK
470
KESPKKYEGG
480
RELSDFISYL
490
QREATNPPII
500
QEEKPKKKKK
AQEDL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0042824 |
MHC class I peptide loading complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0106222 |
lncRNA binding |
| Molecular Function |
GO:0003756 |
protein disulfide isomerase activity |
| Molecular Function |
GO:0044183 |
protein folding chaperone |
| Molecular Function |
GO:0015035 |
protein-disulfide reductase activity |
| Biological Process |
GO:0002502 |
peptide antigen assembly with MHC class I protein complex |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.