Search Results

Overview

Uniprot IDH0VC58
Protein NameATP-dependent 6-phosphofructokinase
Gene NamePFKM
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
678 FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MTHEEHHAAK 20 TLGIGKAIAV 30 LTSGGDAQGM 40 NAAVRAVVRV 50 GIFTGARVFF 60 VHEGYQGLVD 70 GGDNIREATW 80 ESVSMMLQLG 90 GTVIGSARCK 100 DFREREGRLR 110 AAHNLVKRGI 120 TNLCVIGGDG 130 SLTGADTFRS 140 EWSDLLNDLQ 150 KAGKITAEEA 160 KKSSFLNIVG 170 LVGSIDNDFC 180 GTDMTIGTDS 190 ALHRIIEIVD 200 AITTTAQSHQ 210 RTFVLEVMGR 220 HCGYLALVTS 230 LSCGADWVFI 240 PECPPDDDWE 250 EHLCRRLSET 260 RTRGSRLNII 270 IVAEGAIDKN 280 GKPITSEDIK 290 NLVVTRLGYD 300 TRVTVLGHVQ 310 RGGTPSAFDR 320 ILGSRMGVEA 330 VMALLEGTPD 340 TPACVVSLSG 350 NQAVRLPLME 360 CVQVTKDVTK 370 AMDDKRFDEA 380 MKLRGRSFMN 390 NWEVYKLLAH 400 VRPPVSKSGS 410 FTVAVMNVGA 420 PAAGMNAAVR 430 STVRIGLIQG 440 NRVLVVHDGF 450 EGLAKGQIEE 460 AGWSYVGGWT 470 GQGGSKLGTK 480 RTLPKKSFEQ 490 ISANITKFNI 500 QGLVIIGGFE 510 AYTGGLELME 520 GRKQFDELCI 530 PFVVIPATVS 540 NNVPGSDFSV 550 GADTALNTIC 560 TTCDRIKQSA 570 AGTKRRVFII 580 ETMGGYCGYL 590 ATMAGLAAGA 600 DAAYIFEEPF 610 TIRDLQANVE 620 HLVQKMKTTV 630 KRGLVLRNEK 640 CNDNYTTDFI 650 FNLYSEEGKG 660 IFDSRKNVLG 670 HMQQGGSPTP 680 FDRNFATKMG 690 AKAMNWMSGK 700 IKESYRNGRI 710 FANTPDSGCV 720 LGMRKRALVF 730 QPVTELKEQT 740 DFEHRIPKEQ 750 WWLKLRPILK 760 ILAKYEIDLD 770 TSEHAHLEHI 780 SRKRSGEATV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005945 6-phosphofructokinase complex
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0003872 6-phosphofructokinase activity
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0070061 fructose binding
Molecular Function GO:0070095 fructose-6-phosphate binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.