Search Results
Overview
| Uniprot ID | H0VCI4 |
|---|---|
| Protein Name | ATP-dependent chromatin remodeler CHD4 |
| Gene Name | CHD4 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1194 | VRPGLGSKTGSMSKQ |
| 285 | KVAPLKIKLGGFGSK |
| 292 | KLGGFGSKRKRSSSE |
| 684 | LKKVKLRKLERPPET |
Function
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis
Protein Sequence
10
ATSVNPAPLP
20
CHFLSVLCWQ
30
LENEEDPEED
40
LSETETPKLK
50
KKKKPKKPRD
60
PKIPKSKRQK
70
KERLLLCRQL
80
GDSSGEGPEF
90
VEEEEEVALR
100
SDSEGSDYTP
110
GKKKKKKLGP
120
KKEKKSKSKR
130
KEEEEEDDDD
140
DDSKEPKSSA
150
QLLEDWGMED
160
IDHVFSEEDY
170
RTLTNYKAFS
180
QFVRPLIAAK
190
NPKIAVSKMM
200
MVLGAKWREF
210
STNNPFKGSS
220
GASVAAAAAA
230
AVAVVESMVT
240
ATEVAPPPPP
250
VEVPIRKAKT
260
KEGKGPNARR
270
KPKGSPRVPD
280
AKKPKPKKVA
290
PLKIKLGGFG
300
SKRKRSSSED
310
DDLDVESDFD
320
DASINSYSVS
330
DGSTSRSSRS
340
RKKLRTTKKK
350
KKGEEEVTAV
360
DGYETDHQDY
370
CEVCQQGGEI
380
ILCDTCPRAY
390
HMVCLDPDME
400
KAPEGKWSCP
410
HCEKEGIQWE
420
AKEDNSEGEE
430
ILEEVGGDPE
440
EEDDHHMEFC
450
RVCKDGGELL
460
CCDTCPSSYH
470
IHCLNPPLPE
480
IPNGEWLCPR
490
CTCPALKGKV
500
QKILIWKWGQ
510
PPSPTPVPRP
520
PDADPNTPSP
530
KPLEGRPERQ
540
FFVKWQGMSY
550
WHCSWVSELQ
560
LELHCQVMFR
570
NYQRKNDMDE
580
PPSGDFGGDE
590
EKSRKRKNKD
600
PKFAEMEERF
610
YRYGIKPEWM
620
MIHRILNHSV
630
DKKGHVHYLI
640
KWRDLPYDQA
650
SWESEDVEIQ
660
DYDLFKQSYW
670
NHRELMRGEE
680
GRPGKKLKKV
690
KLRKLERPPE
700
TPTVDPTVKY
710
ERQPEYLDAT
720
GGTLHPYQME
730
GLNWLRFSWA
740
QGTDTILADE
750
MGLGKTVQTA
760
VFLYSLYKEG
770
HSKGPFLVSA
780
PLSTIINWER
790
EFEMWAPDMY
800
VVTYVGDKDS
810
RAIIRENEFS
820
FEDNAIRGGK
830
KASRMKKEAS
840
VKFHVLLTSY
850
ELITIDMAIL
860
GSIDWACLIV
870
DEAHRLKNNQ
880
SKFFRVLNGY
890
SLQHKLLLTG
900
TPLQNNLEEL
910
FHLLNFLTPE
920
RFHNLEGFLE
930
EFADIAKEDQ
940
IKKLHDMLGP
950
HMLRRLKADV
960
FKNMPSKTEL
970
IVRVELSPMQ
980
KKYYKYILTR
990
NFEALNARGG
1000
GNQVSLLNVV
1010
MDLKKCCNHP
1020
YLFPVAAMEA
1030
PKMPNGMYDG
1040
SALIRASGKL
1050
LLLQKMLKNL
1060
KEGGHRVLIF
1070
SQMTKMLDLL
1080
EDFLEHEGYK
1090
YERIDGGITG
1100
NMRQEAIDRF
1110
NAPGAQQFCF
1120
LLSTRAGGLG
1130
INLATADTVI
1140
IYDSDWNPHN
1150
DIQAFSRAHR
1160
IGQNKKVMIY
1170
RFVTRASVEE
1180
RITQVAKKKM
1190
MLTHLVVRPG
1200
LGSKTGSMSK
1210
QELDDILKFG
1220
TEELFKDEAT
1230
DGGGDNKEGE
1240
DSSVIHYDDK
1250
AIERLLDRNQ
1260
DETEDTELQG
1270
MNEYLSSFKV
1280
AQYVVREEEM
1290
GEEEEVEREI
1300
IKQEESVDPD
1310
YWEKLLRHHY
1320
EQQQEDLARN
1330
LGKGKRIRKQ
1340
VNYNDGSQED
1350
RDWQDDQSDN
1360
QSDYSVASEE
1370
GDEDFDERSE
1380
APRRPSRKGL
1390
RNDKDKPLPP
1400
LLARVGGNIE
1410
VLGFNARQRK
1420
AFLNAIMRYG
1430
MPPQDAFTTQ
1440
WLVRDLRGKS
1450
EKEFKAYVSL
1460
FMRHLCEPGA
1470
DGAETFADGV
1480
PREGLSRQHV
1490
LTRIGVMSLI
1500
RKKVQEFEHV
1510
NGRWSMPELA
1520
EVEENKKMSQ
1530
PGSPSPKTPT
1540
PSTPGDTQPN
1550
TPAPVPPAED
1560
GIKIEENSLK
1570
EEESPEGEKE
1580
VKSAAPEATV
1590
ECAQPPAPAS
1600
EEEKVLVEPL
1610
EGEEKVEKAE
1620
AKERTEEPME
1630
TEPKGIADVE
1640
KVEEKSAIDL
1650
TPIVVEDKEE
1660
KKEEDDKKEV
1670
MLQNGETPKD
1680
LSDEKQKKNI
1690
KQRFMFNIAD
1700
GGFTELHSLW
1710
QNEERAATVT
1720
KKTYEIWHRR
1730
HDYWLLAGII
1740
NHGYARWQDI
1750
QNDPRYAILN
1760
EPFKGEMNRG
1770
NFLEIKNKFL
1780
ARRFKLLEQA
1790
LVIEEQLRRA
1800
AYLNMSEDPS
1810
HPSMALNTRF
1820
AEVECLAESH
1830
QHLSKESMAG
1840
NKPANAVLHK
1850
VLKQLEELLS
1860
DMKADVTRLP
1870
ATIARIPPVA
1880
VRLQMSERNI
1890
LSRLANRAPE
1900
PPPQQVAQQQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016581 | NuRD complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0090734 | site of DNA damage |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140658 | ATP-dependent chromatin remodeler activity |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0010629 | negative regulation of gene expression |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.