Search Results

Overview

Uniprot IDH0VCI4
Protein NameATP-dependent chromatin remodeler CHD4
Gene NameCHD4
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1194 VRPGLGSKTGSMSKQ
285 KVAPLKIKLGGFGSK
292 KLGGFGSKRKRSSSE
684 LKKVKLRKLERPPET

Function

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis

Protein Sequence

10 ATSVNPAPLP 20 CHFLSVLCWQ 30 LENEEDPEED 40 LSETETPKLK 50 KKKKPKKPRD 60 PKIPKSKRQK 70 KERLLLCRQL 80 GDSSGEGPEF 90 VEEEEEVALR 100 SDSEGSDYTP 110 GKKKKKKLGP 120 KKEKKSKSKR 130 KEEEEEDDDD 140 DDSKEPKSSA 150 QLLEDWGMED 160 IDHVFSEEDY 170 RTLTNYKAFS 180 QFVRPLIAAK 190 NPKIAVSKMM 200 MVLGAKWREF 210 STNNPFKGSS 220 GASVAAAAAA 230 AVAVVESMVT 240 ATEVAPPPPP 250 VEVPIRKAKT 260 KEGKGPNARR 270 KPKGSPRVPD 280 AKKPKPKKVA 290 PLKIKLGGFG 300 SKRKRSSSED 310 DDLDVESDFD 320 DASINSYSVS 330 DGSTSRSSRS 340 RKKLRTTKKK 350 KKGEEEVTAV 360 DGYETDHQDY 370 CEVCQQGGEI 380 ILCDTCPRAY 390 HMVCLDPDME 400 KAPEGKWSCP 410 HCEKEGIQWE 420 AKEDNSEGEE 430 ILEEVGGDPE 440 EEDDHHMEFC 450 RVCKDGGELL 460 CCDTCPSSYH 470 IHCLNPPLPE 480 IPNGEWLCPR 490 CTCPALKGKV 500 QKILIWKWGQ 510 PPSPTPVPRP 520 PDADPNTPSP 530 KPLEGRPERQ 540 FFVKWQGMSY 550 WHCSWVSELQ 560 LELHCQVMFR 570 NYQRKNDMDE 580 PPSGDFGGDE 590 EKSRKRKNKD 600 PKFAEMEERF 610 YRYGIKPEWM 620 MIHRILNHSV 630 DKKGHVHYLI 640 KWRDLPYDQA 650 SWESEDVEIQ 660 DYDLFKQSYW 670 NHRELMRGEE 680 GRPGKKLKKV 690 KLRKLERPPE 700 TPTVDPTVKY 710 ERQPEYLDAT 720 GGTLHPYQME 730 GLNWLRFSWA 740 QGTDTILADE 750 MGLGKTVQTA 760 VFLYSLYKEG 770 HSKGPFLVSA 780 PLSTIINWER 790 EFEMWAPDMY 800 VVTYVGDKDS 810 RAIIRENEFS 820 FEDNAIRGGK 830 KASRMKKEAS 840 VKFHVLLTSY 850 ELITIDMAIL 860 GSIDWACLIV 870 DEAHRLKNNQ 880 SKFFRVLNGY 890 SLQHKLLLTG 900 TPLQNNLEEL 910 FHLLNFLTPE 920 RFHNLEGFLE 930 EFADIAKEDQ 940 IKKLHDMLGP 950 HMLRRLKADV 960 FKNMPSKTEL 970 IVRVELSPMQ 980 KKYYKYILTR 990 NFEALNARGG 1000 GNQVSLLNVV 1010 MDLKKCCNHP 1020 YLFPVAAMEA 1030 PKMPNGMYDG 1040 SALIRASGKL 1050 LLLQKMLKNL 1060 KEGGHRVLIF 1070 SQMTKMLDLL 1080 EDFLEHEGYK 1090 YERIDGGITG 1100 NMRQEAIDRF 1110 NAPGAQQFCF 1120 LLSTRAGGLG 1130 INLATADTVI 1140 IYDSDWNPHN 1150 DIQAFSRAHR 1160 IGQNKKVMIY 1170 RFVTRASVEE 1180 RITQVAKKKM 1190 MLTHLVVRPG 1200 LGSKTGSMSK 1210 QELDDILKFG 1220 TEELFKDEAT 1230 DGGGDNKEGE 1240 DSSVIHYDDK 1250 AIERLLDRNQ 1260 DETEDTELQG 1270 MNEYLSSFKV 1280 AQYVVREEEM 1290 GEEEEVEREI 1300 IKQEESVDPD 1310 YWEKLLRHHY 1320 EQQQEDLARN 1330 LGKGKRIRKQ 1340 VNYNDGSQED 1350 RDWQDDQSDN 1360 QSDYSVASEE 1370 GDEDFDERSE 1380 APRRPSRKGL 1390 RNDKDKPLPP 1400 LLARVGGNIE 1410 VLGFNARQRK 1420 AFLNAIMRYG 1430 MPPQDAFTTQ 1440 WLVRDLRGKS 1450 EKEFKAYVSL 1460 FMRHLCEPGA 1470 DGAETFADGV 1480 PREGLSRQHV 1490 LTRIGVMSLI 1500 RKKVQEFEHV 1510 NGRWSMPELA 1520 EVEENKKMSQ 1530 PGSPSPKTPT 1540 PSTPGDTQPN 1550 TPAPVPPAED 1560 GIKIEENSLK 1570 EEESPEGEKE 1580 VKSAAPEATV 1590 ECAQPPAPAS 1600 EEEKVLVEPL 1610 EGEEKVEKAE 1620 AKERTEEPME 1630 TEPKGIADVE 1640 KVEEKSAIDL 1650 TPIVVEDKEE 1660 KKEEDDKKEV 1670 MLQNGETPKD 1680 LSDEKQKKNI 1690 KQRFMFNIAD 1700 GGFTELHSLW 1710 QNEERAATVT 1720 KKTYEIWHRR 1730 HDYWLLAGII 1740 NHGYARWQDI 1750 QNDPRYAILN 1760 EPFKGEMNRG 1770 NFLEIKNKFL 1780 ARRFKLLEQA 1790 LVIEEQLRRA 1800 AYLNMSEDPS 1810 HPSMALNTRF 1820 AEVECLAESH 1830 QHLSKESMAG 1840 NKPANAVLHK 1850 VLKQLEELLS 1860 DMKADVTRLP 1870 ATIARIPPVA 1880 VRLQMSERNI 1890 LSRLANRAPE 1900 PPPQQVAQQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Cellular Component GO:0090734 site of DNA damage
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0010629 negative regulation of gene expression

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.