Overview
| Uniprot ID | H0VCM3 |
|---|
| Protein Name | Glucose-6-phosphate isomerase |
|---|
| Gene Name | GPI |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 252 |
ALSTNTAKVKEFGID |
| 34 |
RRLFEADKERFNHFS |
| 366 |
SNGKYITKPGVRVDH |
Function
Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P. In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion
Protein Sequence
10
MAALTRNPEF
20
QKLQQWHREH
30
GSDLNLRRLF
40
EADKERFNHF
50
SLTLNTNHGH
60
ILLDYSKNLV
70
TEDVMKMLVE
80
LAKSRGVEAA
90
RERMFSGEKI
100
NYTEDRAVLH
110
VALRNRSNTP
120
MLVDGKDVMP
130
EINKVLDKMK
140
SFCQRVRNGD
150
WKGYTGKAIT
160
DVINIGIGGS
170
DLGPLMVTEA
180
LKPYSSGGPH
190
VWFVSNIDGT
200
HIAKTLANLN
210
PETSLFIIAS
220
KTFTTQETIT
230
NAETAKEWFL
240
MSAKDASAVA
250
KHFVALSTNT
260
AKVKEFGIDP
270
QNMFEFWDWV
280
GGRYSLWSAI
290
GLSIALHVGF
300
DNFEQLLSGA
310
HWMDQHFRTA
320
PLEKNAPVLL
330
ALLGIWYINC
340
FGCETQALLP
350
YDQYLHRFPA
360
YFQQGDMESN
370
GKYITKPGVR
380
VDHQTGPIVW
390
GEPGTNGQHA
400
FYQLIHQGTK
410
MIPCDFLIPV
420
QTQHPIRKGL
430
HHKILLANFL
440
AQTEALMKGK
450
STEEARKELQ
460
AAGKSPGDLE
470
KLLPHKVFEG
480
NRPTNSIVFT
490
KLTPFILGAL
500
IALYEHKIFV
510
QGIIWDINSF
520
DQWGVELGKQ
530
LAKKIEPELD
540
GSAAVTSHDS
550
STNGLINFIK
QQREARTE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0097367 |
carbohydrate derivative binding |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0004347 |
glucose-6-phosphate isomerase activity |
| Molecular Function |
GO:0048029 |
monosaccharide binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0006002 |
fructose 6-phosphate metabolic process |
| Biological Process |
GO:0006094 |
gluconeogenesis |
| Biological Process |
GO:0051156 |
glucose 6-phosphate metabolic process |
| Biological Process |
GO:0006096 |
glycolytic process |
| Biological Process |
GO:0010595 |
positive regulation of endothelial cell migration |
| Biological Process |
GO:0002639 |
positive regulation of immunoglobulin production |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.