Search Results
Overview
| Uniprot ID | H0VCS0 |
|---|---|
| Protein Name | Vesicular inhibitory amino acid transporter |
| Gene Name | SLC32A1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MATLLRSKLSNVATS |
Function
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake
Protein Sequence
10
MATLLRSKLS
20
NVATSVSNKS
30
QAKVSGMFAR
40
MGFQAATDEE
50
AVGFAHCDDL
60
DFEHRQGLQM
70
DILKAEGEPC
80
GEEGAEPPVE
90
GDIHYQRGGG
100
APLPPSGSKD
110
QGMGAGGEFG
120
GHDKPKITAW
130
EAGWNVTNAI
140
QGMFVLGLPY
150
AILHGGYLGL
160
FLIIFAAVVC
170
CYTGKILIAC
180
LYEENEDGEV
190
VRVRDSYVAI
200
ANACCAPRFP
210
TLGGRVVNVA
220
QIIELVMTCI
230
LYVVVSGNLM
240
YNSFPGLPVS
250
QKSWSIIATA
260
VLLPCAFLKN
270
LKAVSKFSLL
280
CTLAHFVINI
290
LVIAYCLSRA
300
RDWAWEKVKF
310
YIDVKKFPIS
320
IGIIVFSYTS
330
QIFLPSLEGN
340
MQQPSEFHCM
350
MNWTHIAACV
360
LKGLFALVAY
370
LTWADETKEV
380
ITDNLPGSIR
390
AVVNIFLVAK
400
ALLSYPLPFF
410
AAVEVLEKSL
420
FQEGSRAFFP
430
ACYGGDGRLK
440
SWGLTLRCAL
450
VVFTLLMAIY
460
VPHFALLMGL
470
TGSLTGAGLC
480
FLLPSLFHLR
490
LLWRKLLWHQ
500
VFFDVAIFVI
510
GGICSVSGFV
520
HSLEGLIEAY
RTNAED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0051286 | cell tip |
| Cellular Component | GO:0044316 | cone cell pedicle |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0044292 | dendrite terminus |
| Cellular Component | GO:0060077 | inhibitory synapse |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0005774 | vacuolar membrane |
| Molecular Function | GO:0140800 | gamma-aminobutyric acid:proton antiporter activity |
| Molecular Function | GO:0140799 | glycine:proton antiporter activity |
| Molecular Function | GO:0015179 | L-amino acid transmembrane transporter activity |
| Biological Process | GO:0051939 | gamma-aminobutyric acid import |
| Biological Process | GO:0006836 | neurotransmitter transport |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.