Overview
| Uniprot ID | H0VD77 |
|---|
| Protein Name | H/ACA ribonucleoprotein complex subunit DKC1 |
|---|
| Gene Name | DKC1 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
AEAITLPKKHKKKKD |
| 443 |
QVVAEAVKITKRKRE |
Function
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme
Protein Sequence
10
MADAEAITLP
20
KKHKKKKDRK
30
SLQEEDVAEI
40
QHAEEFLIKP
50
ESKVAQLDTS
60
QWPLLLKNFD
70
KLNVRTTHYT
80
PLPCGSNPLK
90
REIGDYIRTG
100
FINLDKPSNP
110
SSHEVVAWIR
120
RILRVEKTGH
130
SGTLDPKVTG
140
CLIVCIERAT
150
RLVKSQQSAG
160
KEYVGIVRLH
170
NAIEGGTQLS
180
RALETLTGAL
190
FQRPPLIAAV
200
KRQLRVRTIY
210
ESKMIEYDPE
220
RRLGIFWVSC
230
EAGTYIRTLC
240
VHLGLLLGVG
250
GQMQELRRVR
260
SGVMSEKDHM
270
VTMHDVLDAQ
280
WLYDNHKDES
290
YLRRVVYPLE
300
KLLTSHKRLV
310
MKDSAVNAIC
320
YGAKIMLPGV
330
LRYEDGIEVN
340
QEIVVITTKG
350
EAICMAIALM
360
TTAVISTCDH
370
GIVAKIKRVI
380
MERDTYPRKW
390
GLGPKASQKK
400
MMIKQGLLDK
410
HGKPTDSTPA
420
AWKQEYIDYS
430
DSSKNTLVAE
440
VAKSPQVVAE
450
AVKITKRKRE
460
SESESDETPA
470
AAPKLSKKEK
480
KKKNKDKKAK
490
ATPESGGEPG
500
DGDSDTTKKK
510
KKKKAKVVEV
ASE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031429 |
box H/ACA snoRNP complex |
| Cellular Component |
GO:0090661 |
box H/ACA telomerase RNP complex |
| Cellular Component |
GO:0015030 |
Cajal body |
| Cellular Component |
GO:0001650 |
fibrillar center |
| Molecular Function |
GO:0034513 |
box H/ACA snoRNA binding |
| Molecular Function |
GO:0009982 |
pseudouridine synthase activity |
| Molecular Function |
GO:0003720 |
telomerase activity |
| Molecular Function |
GO:0070034 |
telomerase RNA binding |
| Biological Process |
GO:0000495 |
box H/ACA sno(s)RNA 3'-end processing |
| Biological Process |
GO:0000455 |
enzyme-directed rRNA pseudouridine synthesis |
| Biological Process |
GO:1990481 |
mRNA pseudouridine synthesis |
| Biological Process |
GO:1904874 |
positive regulation of telomerase RNA localization to Cajal body |
| Biological Process |
GO:0031120 |
snRNA pseudouridine synthesis |
| Biological Process |
GO:0090669 |
telomerase RNA stabilization |
| Biological Process |
GO:0007004 |
telomere maintenance via telomerase |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.