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Overview

Uniprot ID	H0VD87
Protein Name	Zinc finger protein 148
Gene Name	ZNF148
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
225	EKIHTGEKPFRCDEC
424	YEESKVSKYAFELVD

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

Protein Sequence

10 MNIDDKLEGL 20 FLKCGDIDEM 30 QSSRAMVVMG 40 GVSGQSAVSG 50 ALQESVLQDR 60 SMPHQEILAA 70 DEVLQESEMR 80 QQDMIPHDEL 90 MVHEETVKND 100 EEQMEAHERL 110 PQGLQYALNV 120 PISVKQEITF 130 TDVSEQLMRD 140 KKQIREPVDL 150 QKKKKRKQRS 160 PAKILTINED 170 GSLGLKTPKS 180 HVCEHCNAAF 190 RTNYHLQRHV 200 FIHTGEKPFQ 210 CSQCDMRFIQ 220 KYLLQRHEKI 230 HTGEKPFRCD 240 ECGMRFIQKY 250 HMERHKRTHS 260 GEKPYQCEYC 270 LQYFSRTDRV 280 LKHKRMCHEN 290 HDKKLNRCAI 300 KSGLLTSEED 310 SGFSTSPKDN 320 SLPKKKRQKA 330 EKKSSGMDKE 340 SALDKSDLKK 350 DKNDYLPLYS 360 SSTKVKDEYM 370 VAEYAVEMPH 380 SSVGGSHLED 390 ASGEIHPPKL 400 VLKKINSKRS 410 LKQPLEQNQT 420 ISPLSTYEES 430 KVSKYAFELV 440 DKQALLDSEG 450 NADIDQVDNL 460 QEGPSKPVHS 470 STNYDDAMQF 480 LKKKRYLQAA 490 SNNSREYALN 500 VGTIASQPSV 510 TQAAVASVID 520 ESTTASILDS 530 QALNVEIKSN 540 HDKNVIPDEV 550 LQTLLDHYSH 560 KANGQHEISF 570 SVADTEVTSS 580 ISINSSEVPE 590 VTPSESVGSS 600 SQASSSDKAN 610 MLQEYSKFLQ 620 QALDRTSQND 630 AYLNSPSLNF 640 VTDNQTLPNQ 650 PAFSSIDKQV 660 YAAMPINSFR 670 SGMNSPLRTT 680 PDKSHFGLIV 690 GDSQHAFPFS 700 GDETNHASAT 710 STQDFLDQVT 720 SQKKAEAQPV 730 HQAYQMSSFE 740 QPFRAPYHGS 750 RAGIAPQFST 760 ANGQVNLRGP 770 GTSAEFSEFP 780 LVNVNDNRAG 790 MTSSPDATTG QTFG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0010629	negative regulation of gene expression

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.