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Overview

Uniprot IDH0VE10
Protein NameHexokinase-2
Gene NameHk2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
346 VSDIEEEKDGIQRTR

Function

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis

Protein Sequence

10 MIASHLIACL 20 FTELNRNQVQ 30 KVDQYLYHMR 40 LSDETLLDIS 50 KRFRKEMEKG 60 LGATTHPTAS 70 VKMLPTFVRS 80 TPDGTEHGEF 90 LALDLGGTNF 100 RVLWVKVTDN 110 GLQKVEMENQ 120 IYAIPEDIMR 130 GSGTQLFDHI 140 AECLANFMDK 150 LQIKDKKLPL 160 GFTFSFPCHQ 170 TKLDESFLVS 180 WTKGFKSSGV 190 EGKDIVALIR 200 EAIRRRGDFD 210 IDIVAVVNDT 220 VGTMMTCGYD 230 DQNCEIGLIV 240 GTGSNACYME 250 EMRHIDMVEG 260 DEGRMCVNME 270 WGAFGDDGAL 280 NDIRTEFDQE 290 IDMGSLNPGK 300 QLFEKMISGM 310 YMGELVRLIL 320 VKMAKEELLF 330 QGKLSPGLLT 340 TGSFETKDVS 350 DIEEEKDGIQ 360 RTRQVLLRLG 370 LDPLQEDCVA 380 TRRVCQIVST 390 RSASLCAATL 400 VAVLRRLKEN 410 KGEDRLRSTI 420 GVDGSVYKKH 430 PHFAKHLHKA 440 VRRLVPDCDV 450 RFLRSEDGSG 460 KGAAMVTAVA 470 YRLADQHRAR 480 QKTLEPLKLS 490 HEQLLEIKRR 500 MKVEMERGLS 510 KETHTVAPVK 520 MLPTYVCATP 530 DGTEKGDFLA 540 LDLGGTNFRV 550 LLVRVRNGKR 560 RGVEMHNKIY 570 SIPQEVMHGT 580 GEELFDHIVQ 590 CIADFLEYMG 600 MKGVSLPLGF 610 TFSFPCQQNS 620 LDESILLKWT 630 KGFKASGCEG 640 EDVVTLLKEA 650 IHRREEFDLD 660 VVAVVNDTVG 670 TMMTCGYEDP 680 HCEVGLIVGT 690 GSNACYMEEM 700 RNVELVDGEE 710 GRMCVNMEWG 720 AFGDNGCLDD 730 FRTEFDVAVD 740 ELSLNPGKQR 750 FEKMISGMYL 760 GEIVRNILID 770 FTKRGLLFRG 780 RISERLKTRG 790 IFETKFLSQI 800 ESDCLALLQV 810 RAILHHLGLD 820 STCDDSIIVK 830 EVCTVVARRA 840 AQLCGAGMAA 850 VVDKIRENRG 860 LDTLKVTVGV 870 DGTLYKLHPH 880 FAKVMHQTVK 890 ELAPKCEVCF 900 LESEDGSGKG 910 AALITAVACR IREAGQR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005741 mitochondrial outer membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008865 fructokinase activity
Molecular Function GO:0004340 glucokinase activity
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0072655 establishment of protein localization to mitochondrion
Biological Process GO:0001678 intracellular glucose homeostasis
Biological Process GO:0072656 maintenance of protein location in mitochondrion
Biological Process GO:0035795 negative regulation of mitochondrial membrane permeability
Biological Process GO:2000378 negative regulation of reactive oxygen species metabolic process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:1905091 positive regulation of type 2 mitophagy

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.