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Overview

Uniprot ID	H0VEI7
Protein Name	Vesicle-fusing ATPase
Gene Name	Nsf
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
102	EIDFLQKKSIDSNPY
158	AMDPSILKGEAATGK

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin

Protein Sequence

10 MPMQAARCPT 20 DELSLTNCAV 30 VNETDFQSNQ 40 HVVVRTSSNH 50 KFTFTLRTHP 60 SVVPGSIAFS 70 LPQRKWAGLS 80 IGQEIEVSLY 90 TFDKAKQCIG 100 TMTIEIDFLQ 110 KKSIDSNPYD 120 TDKMAAEFIQ 130 QFNNQAFSVG 140 QQLVFSFNEK 150 LFGLLVKDIE 160 AMDPSILKGE 170 AATGKRQKIE 180 VGLVVGNSQV 190 AFEKAEKSSL 200 NLIGKAKTKE 210 NRQSIINPDW 220 NFEKMGIGGL 230 DKEFSDIFRR 240 AFASRVFPPE 250 IVEQMGCKHV 260 KGILLYGPPG 270 CGKTLLARQI 280 GKMLNAREPK 290 VVNGPEILNK 300 YVGESEANIR 310 KLFADAEEEQ 320 RRLGANSGLH 330 IIIFDEIDAI 340 CKQRGSMAGS 350 TGVHDTVVNQ 360 LLSKIDGVEQ 370 LNNILVIGMT 380 NRPDLIDEAL 390 LRPGRLEVKM 400 EIGLPDEKGR 410 LQILHIHTAR 420 MRDHQLLSTD 430 VDIKELAVET 440 KNFSGAELEG 450 LVRAAQSTAM 460 NRHIKASTKV 470 EVDMEKAESL 480 KVTRGDFLAS 490 LENDIKPAFG 500 TNQEDYASYI 510 MNGIIKWGDP 520 VTRVLDDGEL 530 LVQQTKNSDR 540 TPLVSVLLEG 550 PPHSGKTALA 560 AKIAEESNFP 570 FIKICSPDKM 580 IGFSETAKCQ 590 AMKKIFDDAY 600 KSQLSCVVVD 610 DIERLLDYVP 620 IGPRFSNLVL 630 QALLVLLKKA 640 PPQGRKLLII 650 GTTSRKDVLQ 660 EMEMLHAFST 670 TIHVPNIATG 680 EQLLEALELL 690 GNFKDKERTT 700 ISQQVKGKKV 710 WIGIKKLLML 720 IEMSLQMDPE 730 YRVKKFLALL REEGA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005795	Golgi stack
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0043001	Golgi to plasma membrane protein transport
Biological Process	GO:0006891	intra-Golgi vesicle-mediated transport
Biological Process	GO:0035494	SNARE complex disassembly

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.