Search Results
Overview
| Uniprot ID | H0VEM1 |
|---|---|
| Protein Name | Glutathione S-transferase LANCL1 |
| Gene Name | LANCL1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | YHRTNNEKQAEDCIT |
Function
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione
Protein Sequence
10
MAQRAFPNPY
20
ADHNKSLAEG
30
YFDSAGRLTP
40
EFSQRVTNKI
50
QELLQQMERG
60
LKSADPRDGT
70
AYTGWAGIAV
80
LYLHLHEVFG
90
DPAYLQMAHS
100
YVKQSLNCLS
110
RRSITFLCGD
120
AGPLAVAAAL
130
YHRTNNEKQA
140
EDCITRLVHL
150
NKIDPHAPNE
160
LLYGRIGYIY
170
ALLFVNKNFG
180
TEKIPQSHIQ
190
QICETILTSG
200
ENLARKRNFT
210
AKSPLMYEWY
220
QEYYVGAAHG
230
LAGIYYYLMQ
240
PSLQVSQAKL
250
QSLVKPSVDF
260
VCQLKFPSGN
270
YPPCLDDNRD
280
LLVHWCHGAP
290
GVIYMLTQAY
300
KVFGEERYLS
310
YAYQCADVVW
320
QHGLLKKGYG
330
LCHGAAGNAY
340
AFLTLYNLTQ
350
DHKYLYRACK
360
FAEWCLDYGE
370
HGCRTPDTPF
380
SLFEGMAGTI
390
YFLADLLVPT
KAKFPAFEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:1990748 | cellular detoxification |
| Biological Process | GO:0031179 | peptide modification |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.